Statins Tip Sheet: Decreased SLCO1B1 Function


The following information is intended for use by providers who are attempting to prescribe statins (except rosuvastatin) to patients with certain SLCO1B1 genetic variants.

For immediate questions, send a secure chat message to Groups: Pharmacogenomics Service in UCHealth's EHR.

Patient Education Resources

Clinicians using the UCHealth EHR can use dotphrase: .pgxstatintopatient
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  1. Link E, et al. SLCO1B1 variants and statin-induced myopathy--a genomewide study. New Engl J Med 2008; 359(8): 789-799.
  2. Voora D, et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol 2009; 54(17):1609-1616.
  3. Grundy SM, et al. 2018 Guideline on the management of blood cholesterol: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019; 73(24):3237-3241.
  4. Cooper-DeHoff RM, Niemi M, Ramsey LB, et al. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. Clin Pharmacol Ther. 2022;111(5):1007-1021.
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