Codeine and Tramadol Tip Sheet


The following information is intended for use by providers who are attempting to prescribe codeine or tramadol to patients with certain CYP2D6 genetic variants.  

For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.

Patient Education Resources

Clinicians using the UCHealth EHR can use dotphrase: .pgxcodeinetramadoltopatient 

Reference: Crews et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021 Oct;110(4):888-896. PMID: 33387367.

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