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Research Highlights
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An RNA Pseudoknot stimulates HTLV-1 pro-pol Programmed -1 Ribosomal Frameshifting
Oct 29, 2020 byProgrammed -1 ribosomal frameshifts (-1 PRFs) are commonly used by viruses to regulate their enzymatic and structural protein levels...Full story -
Coding regions affect mRNA stability in human cells
Oct 28, 2020 byA new paradigm has emerged that coding regions can regulate mRNA stability in model organisms...Full story -
Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism
Oct 27, 2020 byControl of transcription speed, which influences many co-transcriptional processes, is poorly understood...Full story -
How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay
Oct 26, 2020 byNonsense-mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control process that serves both as a mechanism to eliminate aberrant transcripts carrying premature stop codons, and to regulate expression of some normal transcripts...Full story -
Classical and emerging techniques to identify and quantify localized RNAs
Oct 25, 2020 byIn essentially every cell, proteins are asymmetrically distributed according to their function. For many genes, this protein sorting problem is solved by transporting RNA molecules encoding the protein, rather than the protein itself, to the desired subcellular location...Full story -
Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response
Oct 24, 2020 byn the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity...Full story