Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.

Dates of Funding: 2018-2019
My research to date has focused on the regulation of utero-placental function by environmental and endocrine factors and its role in the determination of fetal growth and offspring health. This interest began at the Centre for Trophoblast Research at the University of Cambridge. During my PhD I gained extensive experience of in vivo techniques in rodents, including experiments in pregnant animals and large-cohort, multigenerational studies investigating the feto-placental effects of glucocorticoids. In this period, I also obtained proficiency in gene and protein expression and morphometric analyses. I continued my research in this area during postdoctoral training at Cambridge, gaining additional experience of large animal metabolic studies and chronic catheterization techniques in sheep whilst also investigating more deeply the molecular actions of glucocorticoids in the placenta as part of a transcriptomic and bioinformatic project funded by a personal award from the British Society for Endocrinology. My rodent studies culminated in the publication of a series of papers on placental function during maternal stress which garnered interest in the scientific and UK national press. Subsequently, I took up a second postdoctoral position at University College London working upon a more translational project, aiming to develop a therapy for severe intrauterine growth restriction by targeting gene therapy to the uterine arteries in pregnant women. As part of this project, I expanded my expertise in cardiovascular physiology, overseeing protocols for measurement of blood pressure and cardiac morphology in guinea pigs. I moved to the University of Colorado in 2016 in order to gain additional experience in translational reproductive science, in particular capitalizing upon the enhanced opportunities for collaboration with clinical colleagues and access to human tissue available at Anschutz Medical Campus. As a result of this research, I have published 21 research papers (10 first author, including 2 based on my work in Colorado), 8 review articles and over 20 conference papers since 2010. The focus of my current research is the molecular mechanisms by which offspring cardiac dysfunction is programmed in utero in maternal obesity and I have recently reported that normalization of maternal adiponectin levels in obese pregnant mice prevented the development of diastolic dysfunction.  Thus, my research links maternal obesity and nutrition during pregnancy with the long term programming of metabolic disease in children.