Ana Pinto PhD
Dates of Funding: 2023-2025
I am a Postdoctoral Fellow in the Division of Endocrinology, Metabolism and Diabetes at the University of Colorado Anschutz Medical Campus. My research interest is to test and optimize physical activity and sedentary behavior interventions in adults at risk for chronic diseases. Reductions in postprandial glucose responses following active breaks to sitting are more pronounced in females than males over the short-term (<3 days). However, gaps in knowledge remain, including the mechanisms underpinning sex differences in glycemia responses and whether greater benefits are sustained over time. For my Colorado NORC pilot award, I propose to compare the 1-month effects of breaking up prolonged sitting on postprandial glucose responses, and skeletal muscle mitochondrial function and molecular pathways involved in glucose regulation in female versus male adults with prediabetes. Because hyperglycemia is a risk factor for type 2 diabetes and associated cardiovascular complications, determining those mechanisms may provide robust data to promote active breaks to sitting and better tailor physical activity prescription for the prevention of type 2 diabetes and cardiovascular diseases, particularly in females who are more vulnerable to these diseases.