Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.

Dates of funding: 2018-2019
While breastfeeding is known to improve neonatal and long-term health outcomes in humans, many mothers, especially those with obesity or insulin resistance, have difficulty initiating and/or maintaining sufficient milk production to sustain breastfeeding. Exclusive and extended lactation protects against subsequent metabolic impairments in these mothers, who are at increased risk of developing type 2 diabetes, and in their offspring, who are at elevated risk for prediabetes during youth. However, basic biological mechanisms and physiological processes regulating lactation initiation and adequate milk production remain poorly understood. The focus of this proposal is to evaluate insulin signaling in mammary epithelial cells in women with insulin resistance during pregnancy with regard to their lactation outcomes. The results from this study will lay a foundation upon which to develop rational interventions and/or therapeutic strategies to improve breastfeeding outcomes.