Current and Past Colorado NORC Pilot Awardees

Funding Year 2024

Funding Year 2023

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2022

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2021

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2020

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2019

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2018

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2017

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2016

Funding Year 2015

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Funding Year 2014

Jennifer Blankenship

Jennifer Blankenship PhD

Dates of Funding: 2018-2019
The overall goal of my research program is to understand the biological mechanisms by which exercise, sleep, and nocturnal metabolism influence risk for cardiovascular disease, diabetes, and obesity. Sleep has emerged as a key behavior that influences the risk of obesity and obesity related co-morbidities (e.g., diabetes, cardiovascular disease). During sleep, there are many dynamic changes in hormones and metabolites, such as secretion pulses in growth hormone and oscillations in glucose concentrations. Recent studies by my mentors have demonstrated that nocturnal free fatty acid concentrations and nocturnal fat oxidation are related to next day insulin sensitivity and risk for future weight gain. Further, disruptions in sleep quality, independent of sleep quantity, may cause many impairments in metabolism (e.g. insulin resistance, hyperglycemia) and increase the risk of weight gain. Collectively, these data indicate that nocturnal fat metabolism and sleep quality are related to clinically relevant health outcomes and represent an important and understudied area in the field of nutrition and obesity research. 

Individuals with obesity and metabolic syndrome (MetS) have an increased risk of chronic disease and frequently report sleep problems. Disrupted sleep quality may exacerbate the metabolic defects already present in individuals with MetS, thus, determining methods to positively impact sleep in this population is of great importance. Exercise has been a cornerstone of behavioral modifications to treat obesity for decades. There is evidence to suggest exercise improves sleep quality in healthy populations. However, the effect of exercise on sleep quality in individuals with underlying metabolic disease (e.g. obesity, MetS) is not known. Understanding whether exercise positively impacts sleep quality in this population is key in managing chronic disease risk. My current research is investigating how exercise impacts sleep quality and nocturnal metabolism in individuals with MetS.  I expect my findings will provide insight into how exercise and sleep interact to reduce chronic disease risk.

Colorado Nutrition Obesity Research Center (NORC)

CU Anschutz Health and Wellness Center

12348 East Montview Boulevard

Aurora, CO 80045


norc@cuanschutz.edu

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