My role in the NORC is to facilitate the development of our junior investigators through the Pilot Project Program and as the Associate Director, to facilitate team clinical science through fostering collaborative research at the AHWC and clinical research groups affiliated with the NORC. My research group has conducted studies relating to the regulation of body weight and the clinical problem of obesity for more than 30 years. Our studies have examined the basic physiological mechanisms involved in the regulation of body weight using a strategy of measuring responses in appetite, metabolism and energy expenditure to interventions that alter energy balance (overfeeding, underfeeding, reduced or increased physical activity) in animals or human subjects that vary in their propensity to gain weight (naturally thin/obesity resistant, obesity prone, reduced obese). We have used a range of tools for these studies including indirect calorimetry (hood and room), functional brain imaging, controlled feeding studies, direct measures of physical activity, doubly labeled water, tracer measures of nutrient metabolism and metabolite turnover, analysis of cellular responses in skeletal muscle and adipose tissue to name a few. I am currently PI of an R01 evaluating adaptive responses to overfeeding during weight loss maintenance following weight loss in adults in overweight and obesity (R01 DK114272 NCE). I am also currently PI on three industry sponsored clinical trials of newer highly effective antiobesity medications including semaglutide/cagrilintide, retatrutide and tirzepatide. I have also served as an Associate Director of the Colorado Nutrition Obesity Research Center (NORC) for the last 14 years and previously served as the director of the NORC Clinical Intervention and Translation (CIT) Core. I am currently the Director of the Anschutz Health and Wellness Center (AHWC) which is a research resource for UC. I previously served on the Clinical and Integrative Diabetes and Obesity study section of the NIH and Chaired this study section in 2011-12.