The Colorado NORC is managed by an Executive Committee comprised of the NORC Director, Associate Director, Core Directors, and Regular Members. An External Advisory Board advises our committee on major policy decisions and annually reviews the Colorado NORC's progress.
Email Address:nancy.krebs@cuanschutz.edu
Primary Phone:3037243260
Research Complex II
12700 East 19th Avenue
Room 5025
Aurora, CO 80045
Professor of Pediatrics, Head, Section of Nutrition, Associate Vice Chair, Academic Affairs, Dept of Pediatrics
My primary research interests in maternal and infant nutrition extend from detailed metabolic studies of zinc and iron across the life cycle, to large scale RCT of supplements and/or food-based interventions. The focus of these studies has been to define dietary micronutrient requirements and to characterize homeostasis, including metabolic regulation and adaptation to different physiologic states, in normal infants, pregnant & lactating women. I have extensive experience directing intervention trials to monitor and evaluate growth and development in infants and toddlers. Currently I direct the ongoing analyses of the preconception maternal nutrition intervention trial (“Women First”) in 4 low resource countries. Outcomes from birth through 24 months include those of public health interest (birth anthropometry, infant/child stunting rates) plus extensive maternal and infant phenotyping, e.g. metabolomics, microbiome and epigenetic data. My research laboratory extensively employs mass spectrometry (ICP-MS) to measure stable isotope tracers and multi-element mineral analyses in biological and food samples, and we conduct multiple ELISA’s for biomarkers of nutritional status.
In recent years our emphasis on studies in Denver has focused on risk factors in the first 1000 days, including effects of maternal obesity on milk production, bioactive compounds in human milk and the impact on offspring risk for excessive weight gain. We have also conducted interventions modifying the composition of complementary foods and evaluated the effects on growth, adiposity, microbiome and metabolomics. Current studies include a trial of different iron intakes in healthy formula fed newborns; outcomes include effects on the enteric microbiome, systemic and intestinal inflammation, innate immunity and metabolomics.