Eligibility Criteria for LIIA Research Study

Inclusion Criteria

You may be eligible for this research study if you:

• Are between the ages of 60 and 89
• Have a reliable study partner who has frequent (i.e., at least twice per month) contact with the subject and is able to provide information about functional abilities
• Are in range on the brief cognitive screening exam
• Have no informant report of significant cognitive decline in prior year
• Have no evidence from the screening visit suggesting a neurodegenerative disorder
• Are willing to complete both baseline and 24-month follow-up procedures

Exclusion Criteria

You may not be eligible if you have the following:

• Major psychiatric disorder (e.g., schizophrenia, bipolar disorder, untreated major depression within past year)**
• Neurological conditions affecting cognition (e.g., Parkinson’s disease, Mild Cognitive Impairment)
• Immune conditions and other conditions affecting cognition (e.g., lupus, respiratory failure)
• Systemic illnesses (e.g., current cancer, renal failure, respiratory failure)
• Substance abuse/dependence (DSM-V criteria)
• Current medication use likely to affect the nervous system and cognition (e.g., long-acting benzodiazepines; neuroleptics in the phenothiazine and haloperidol families)
• Current medication use that precludes lumbar punctures (e.g., anticoagulants, antiplatelets, heparin shots, or some other types of blood thinner medications: Warfarin [coumadin], Pradaxa [dabigatran], Xarelto [rivaroxaban], Eliquis [apixaban), or Plavix [clopidogrel]).
• Significant sensory or motor deficits that would interfere with cognitive testing
• Factors that preclude MR imaging (e.g., pacemaker)
• Factors that preclude lumbar punctures (e.g., lower back surgery) 

**Prospective participants who previously received a diagnosis of major depression in the past 2 years, but are actively being treated with an anti-depressant and are not reporting significant mood symptoms at study entry may still be considered for enrollment.