Paula Grissom, BS - Senior Professional Research Assistant
Contact Information
Email: Paula.Grissom@cuanschutz.edu
Biography
Paula Grissom is a Senior Professional Research Assistant who joined Dr. Huntington Potter’s laboratory in July 2018. She previously worked for 36 years in the laboratory of Dr. Richard McIntosh at the University of Colorado, Boulder, investigating kinesin and dynein motor proteins and their roles in mitosis. More recently, she studied centromeric proteins that attach chromosomes to microtubules and are required for proper chromosome segregation. Her research in Dr. Potter’s laboratory is focused on how amyloid-beta peptides inhibit the activity of kinesin motors, which results in the disruption of intracellular transport and leads to chromosome mis-segregation and aneuploidy. She is also characterizing a set of small molecules discovered in a screen to identify drugs that block amyloid-beta-mediated inhibition of kinesin motor proteins, which may serve as a new therapeutic approach to Alzheimer’s disease. She is also testing the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) mimetics as a more cost-effective therapy for Alzheimer’s disease and potentially many other disorders.