Christina Coughlan, PhD - Assistant Research Professor

Headshot of Christina Coughlan

Contact Information

Email: Christina.Coughlan@cuanschutz.edu

Education

Postdoctoral Fellowship, University of Pennsylvania

PhD, University College Dublin

Professional Titles

Director, Biorepository Core

Co-Director, Exosome Core

Biography

Christina Coughlan is an Assistant Research Professor in the Department of Neurology, Director of the Biorepository Core, Co-Director of the Exosome Core, a member of the University of Colorado Alzheimer’s and Cognition Center (CUACC), and a member of the Linda Crnic Institute for Down Syndrome. Dr. Coughlan’s research and teaching experience have been extensive, resulting in publications focused on topics that pertain to the safety and efficacy of GM-CSF/sargramostim in the treatment of Alzheimer’s disease, the role of astrogliosis in memory and its decline, the analysis of the role of exosomes in physiology and pathology, diseases, and disorders that include, but are not limited to, Alzheimer’s disease, Down syndrome, cancer, fibrotic lung tissue, fatty liver disease, and immune system dysregulation. Other research interests include understanding the roles of exosomes in the entry and transmission of viruses, detailed examinations of the cellular processes involved in protein mis-folding and clearance, understanding the role of APP and its fragments in the development of Alzheimer’s disease, investigating the role(s) of chemokines in neuroinflammation and neuronal migration, sialylation and its role in post-translational modifications of neural cell adhesion molecule and the role(s) of these modifications in memory formation. Prior to joining CU Anschutz and the CU Alzheimer's and Cognition Center, Dr. Coughlan did postdoctoral fellowships at the University of Pennsylvania, the University of Pittsburgh, and was an Assistant Professor of Biology at the University of Denver.

Recent Publications

Potter H, Woodcock JH, Boyd TD, Coughlan CM, O'Shaughnessy JR, Borges MT, Thaker AA, Raj AB, Adamszuk K, Scott D, Adame V, Anton P, Chial HJ, Gray H, Daniels J, Stocker ME, Sillau SH. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease. Alzheimer's Dement. 2021;7:312158. https://doi.org/10.1002/trc2.12158

Coughlan CM, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, Koenigshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 Sep; 88(1):e110. PMID: 32633898.

Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-ß, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 Mar 16; 221(7):1088-1097. PMID: 31665341.

A list of Dr. Coughlan's publications can be found on Colorado PROFILES