Ming-Feng Tsai, PhD
Assistant Professor

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Ming-Feng Tsai, PhD

Department of Physiology and Biophysics
University of Colorado School of Medicine

RC1 North Tower, P18-7105
Mail Stop 8307
Aurora, CO 80045

E-mail: ming-feng.tsai@cuanschutz.edu

External website: http://www.tsaislab.org/

Our research focuses on molecular mechanisms and physiological functions of transporters and ion-channels, particularly Ca2+ transport proteins in mitochondria. We approach questions using a wide range of tools, including membrane-biochemistry, electrophysiology, cryo-electron microscopy, and live-cell imaging.

Please visit our external website (www.tsaislab.org) for current projects and available positions.

Chen-Wei Tsai

Chen-Wei Tsai, MD, PhD

Postdoctoral Fellow


Madison Rodriguez

Madison Rodriguez

Graduate Student



Tsai Lab 2023

Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF*, Feng L. Structure and mechanism of the mitochondrial calcium uniporter holocomplex. Nature. (2020) 582: 129-133. *Co-corresponding.

Phillips CB, Tsai CW, & Tsai MF. The Conserved Aspartate Ring of MCU Mediates MICU1 Binding and Regulation in the Mitochondrial Calcium Uniporter Complex. eLife. (2019) 8: e41112.

Tsai CW & Tsai MF. Electrical Recordings of the Mitochondrial Calcium Uniporter in Xenopus Oocytes. Journal of General Physiology. (2018) 150: 1035-1043.

Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, & Tsai MF. Proteolytic Control of the Mitochondrial Calcium Uniporter Complex. Proc Natl Acad Sci U S A. (2017) 114: 4388-4393.

Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Williams C, & Miller C. Dual Functions of a Small Regulatory Subunit in the Mitochondrial Calcium Uniporter. eLife. (2016) 5: e15545.

Tsai MF, & Miller C. Building a Temperature-Sensitive Ion Channel. Cell. (2015) 158: 977-979

Tsai MF, Jiang D, Zhao L, Clapham D, & Miller C. Functional Reconstitution of the Mitochondrial H+/Ca2+ Exchanger Letm1. Journal of General Physiology. (2014) 143: 67-73.

Tsai MF, McCarthy P, & Miller C. Substrate Selectivity in Glutamate-Dependent Acid Resistance in Enteric Bacteria. Proc Natl Acad Sci U S A. (2013) 110: 5898-5902.

Tsai MF, & Miller C. Substrate Selectivity in Arginine-Dependent Acid Resistance in Enteric Bacteria. Proc Natl Acad Sci U S A. (2013) 110: 5893-5897.

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