Lab Overview

Raphael Nemenoff is currently the Director of Basic Research in the Division of Renal Diseases and Hypertension.  His laboratory is focused on the role of the microenvironment in mediating disease progression, focusing on inflammatory and immune pathways.  Ongoing projects are currently examining this in models of lung cancer progression, as well as in polycystic kidney disease.  His laboratory has developed new preclinical models for cancer that have been shared with investigators around the world, and is focused on testing new therapeutic approaches that regulate immunity in disease models.  In addition to analyzing cell populations, the lab is performing functional genomic screens in both projects to identify specific genes and pathways regulating progression.  Finally the lab is developing microbots that can be targeted to disease sites using magnetic fields as a novel approach to target therapy.  He is involved in both the Pharmacology and Cancer Biology Training Programs.  He has trained over 25 Fellows and has mentored 6 junior faculty in the Department of Medicine.  He has active collaborations with Drs. Weiser-Evans, Thurman and Hopp.