Skip to content
University of Colorado Anschutz Medical Campus CU Anschutz
  • Webmail
  • UCD Access
  • Canvas
  • Quick Links
 

Tools & Resources

  • Events Calendar
  • Newsroom
  • Strauss Health Sciences Library
  • Department A-Z Directory
  • Campus Directory
  • Leadership
  • Faculty & Staff Resources
  • Supporter & Alumni Resources
  • Student Resources
  • Mental Health Resources
  • Campus Map
  • University Policies
  • Give Now

CU Campuses

  • CU Anschutz Medical Campus
  • CU Boulder
  • CU Colorado Springs
  • CU Denver
  • CU System
  • CU Online

CU Anschutz Medical Campus

  • School of Dental Medicine
  • Graduate School
  • School of Medicine
  • College of Nursing
  • Skaggs School of Pharmacy and Pharmaceutical Sciences
  • Colorado School of Public Health

Department of Orthopedics

School of Medicine

  • Research
  • Iyer Lab
  • Lab Members
  • Our Research
  • Publications

    Our Research

    Iyer Lab

    The Role of ER Sensor Proteins and Unfolded Protein Response (UPR):

    The health of the endoplasmic reticulum (ER) is monitored by a triad of ER sensor transmembrane proteins: ATF6, Ire1a, and Perk. Accumulation of misfolded proteins in the ER leads to ER stress, activating these sensor proteins and initiating the Unfolded Protein Response (UPR) to restore homeostasis. However, if protein folding remains unresolved, elevated UPR can stimulate cytokine production and cell death.

    Exploring ER-Associated Degradation (ERAD) and Misfolded Protein Clearance: Another critical aspect of ER homeostasis is ER-associated degradation (ERAD), a retrograde pathway responsible for recognizing and clearing misfolded proteins from the ER.

    Role of UPR Genes in Skeletal Health and Pathology: In the Iyer Lab, we utilize mouse models to investigate the role of UPR genes in osteoblast lineage cells. By deleting specific UPR genes, we aim to understand the mechanisms by which the UPR regulates osteoblast differentiation and bone mass. Furthermore, we study how UPR dysregulation contributes to pathologic bone loss.

    Role of ERAD in Bone Health: We also explore the role of ERAD in the acquisition of adult bone using murine models. Through collaboration with Dr. Ling Qi from the University of Michigan, we aim to unravel the significance of ERAD in maintaining optimal bone health.

    By delving into these areas of research, the Iyer Lab aims to advance our understanding of ER homeostasis, UPR, ERAD, and their crucial roles in skeletal health and pathology.

    For more information about our ongoing research projects and collaborations, please visit our lab's website or contact us directly.

    Orthopedics (SOM)

    CU Anschutz

    Academic Office One

    12631 East 17th Avenue

    4602

    Aurora, CO 80045


    303-724-2955

    Facebook Twitter Instagram
    Campus Links
    • Anschutz Medical Campus
    • School of Medicine
    • Campus Directory
    • Maps
    Clinical Services
    • Adult Reconstruction
    • Upper Extremity
    • Foot & Ankle
    • Sports Medicine
    • Spine
    • Orthopedic Oncology
    • Make an Appointment
    • Pediatric Orthopedics
    • Trauma & Fracture
    General
    • Find a Doctor
    • Contact Us
    • Patient Care
    • News & Media
    • Contact Us
    • Website Feedback
    • CU System
    • Privacy Policy
    • Terms of Use
    • Accessibility
    • Accreditation
    • Employment
    • Give Now
     

    © 2023 The Regents of the University of Colorado, a body corporate. All rights reserved.

    Accredited by the Higher Learning Commission. All trademarks are registered property of the University. Used by permission only.

    CMS Login

    Webmail

    UCD Access

    Canvas

    Opens in a new window Opens document in a new window