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Department of Orthopedics
School of Medicine
Welcome to Iyer Lab
Lab Director, Srividhya Iyer, PhD
Welcome to Iyer Lab
Srividhya Iyer, PhD
Assistant Professor of Orthopedics
Research Focus: Role of Endoplasmic Reticulum (ER) Homeostasis in Context of Skeletal Health
Our research focuses on investigating the critical role of endoplasmic reticulum (ER) homeostasis in the context of skeletal health. Specifically, we explore the intricate relationship between ER function and osteoblasts, the bone matrix synthesizing cells. Osteoblasts heavily rely on their extensive ER for efficient secretion of proteins essential for bone formation.
Key Research Areas:
ER Stress and Unfolded Protein Response (UPR): We investigate the consequences of protein misfolding and accumulation within the ER, leading to ER stress. This stress triggers a cellular response called the Unfolded Protein Response (UPR), aimed at restoring ER homeostasis.
Molecular Mechanisms of ER-Mediated Osteoblast Differentiation: Our laboratory employs innovative approaches, including cell-specific deletion of UPR genes in mouse models, as well as state-of-the-art fluorescence and electron microscopy-based bone imaging techniques. Through these methods, we aim to elucidate the molecular mechanisms by which the ER regulates osteoblast differentiation.
By uncovering the intricate interplay between ER homeostasis and osteoblast function, our research seeks to advance our understanding of skeletal health at the molecular level. Ultimately, we aim to contribute to the development of novel therapeutic strategies for bone-related disorders and improve patient outcomes.
For more information about our ongoing research projects and publications, please visit our lab's website or contact us directly.
Projects
The health of the ER is monitored by a triad of ER sensor transmembrane proteins ATF6, Ire1a, and Perk. Accumulation of misfolded proteins in the ER results in ER stress and activates the sensor proteins and initiates the Unfolded Protein Response (UPR) to restore homeostasis. If protein folding is unresolved, elevated UPR induces stimulates cytokine production and cell death. Another aspect of ER homeostasis is the ER associated degradation (ERAD) - a retrograde pathway that recognizes and clears misfolded proteins from the ER.
Publications
Contact Us
Contact Us
Iyer Lab
Mail Stop 8343
Research Complex 1 North
12800 E. 19th Avenue,
RC1N 3106
Aurora, CO 80045