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Department of Orthopedics

School of Medicine

Welcome to Cheryl Ackert-Bicknell Lab

Lab Director, Cheryl L. Ackert-Bicknell, Ph.D.

  • Research
  • Ackert-Bicknell Lab
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    Cheryl L Ackert-Bicknell, Ph.D.

    Cheryl L Ackert-Bicknell, Ph.D.

    Associate Professor of Orthopedics

    Welcome to Ackert-Bicknell Lab

    Ackert-Bicknell-Lab-Chromosome

    We focus on the genetic regulation of bone mass and the genetic causes of bone disease from the point of view of bone formation and strength.  We use both forward and reverse genetics studies to interrogate the genetic causes of phenotypes critical to understanding bone quality that cannot be readily studied in human populations. These phenotypes of interest include bone composition, bone formation and mineralization by the osteoblast.  In addition, we participate in many human cohort studies aimed at understanding the etiology of musculoskeletal disease wherein we determine the biological function of genes found to be associated with musculoskeletal traits. Lastly, we study the diagnosis of and the consequences of postoperative infection, with an emphasis on an infection associated with spinal instrumentation.   

    LAB MEMBERS

    OUR RESEARCH

    PUBLICATIONS

    Systems Genetics

    Projects

    Systems Genetics

    The goal of this project is to genetically dissect one of the most of Osteoblast Activity important processes affecting bone, osteoblast-mediated bone formation. We hypothesize that by focusing on a cellular phenotype and employing systems genetics methodologies, we will have increased success in discovering genes that specifically modulate bone formation, as compared to traditional mapping studies of higher-level phenotypes.

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    Publications

    1. Maynard RD, Ackert-Bicknell CL. Mouse Models and Online Resources for Functional Analysis of Osteoporosis Genome-Wide Association Studies. Front Endocrinol (Lausanne). 2019;10:277. doi: 10.3389/fendo.2019.00277. eCollection 2019. Review. PubMed PMID: 31133984; PubMed Central PMCID: PMC6515928.
    2. Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR. Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass. PLoS Genet. 2019 May 1;15(5):e100812
    3. Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens C, Rivadeneira F, Kiel DP, Karasik D. 2019. Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019 Mar 19:e3698.

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    Contact Us

    Ackert-Bicknell Lab

    Mail Stop 8343
    Research Complex 1 North
    12800 E. 19th Avenue,
    Room 2102
    Aurora, CO 80045

    Office: 303-724-6623

    Cheryl.ackert-bicknell@cuanschutz.edu


    Orthopedics (SOM)

    CU Anschutz

    Academic Office One

    12631 East 17th Avenue

    4602

    Aurora, CO 80045


    303-724-2955

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