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PHISM

Pre-clinical Human Immune System Mouse model

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PUBLICATIONS & DOIs

Juan A. Marín-Jiménez¹, Anna Capasso², Matthew S. Lewis³, Stacey M. Bagby⁴, Sarah J. Hartman⁴, Jeremy Shulman³, Natalie M. Navarro⁴, Hui Yu⁵, Chris J. Rivard⁵, Xiaoguang Wang³, Jessica C. Barkow³, Degui Geng⁴, Adwitiya Kar⁶, Ashley Yingst⁷, Dejene M. Tufa⁷, James T. Dolan⁸, Patrick J. Blatchford⁹, Brian M. Freed^3,10, Raul M. Torres^3,5, Eduardo Davila⁴, Jill E. Slansky^3,5, Roberta Pelanda^3,5, S. Gail Eckhardt², Wells A. Messersmith^4,5, Jennifer R. Diamond^4,5, Christopher H. Lieu⁴, Michael R. Verneris⁷, Jing H. Wang^3,5, Katja Kiseljak-Vassiliades^5,6, Todd M. Pitts^4,5 and Julie Lang. 2021. Testing cancer immunotherapy in a human immune system mouse model: correlating treatment responses to human chimerism, therapeutic variables and immune cell phenotypes. Front Immunol. doi: 10.3389/fimmu.2021.PMID: 607282.
Capasso, A*, Lang J*, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, and Eckhardt SG. 2019. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunotherp Cancer 7(1):37. PMID: 30736857.
Lanis JM, Lewis MS, Strassburger H, Larsen K, Bagby SM, Dominguez ATA, Marín-Jiménez JA, Pelanda R, Pitts TM, Lang J. Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors. J Vis Exp. 2022 Dec 16; PubMed Central PMCID: PMC11167650.
Lang J, Leal AD, Marín-Jiménez JA, Hartman SJ, Shulman J, Navarro NM, Lewis MS, Capasso A, Bagby SM, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu CH, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Front Oncol. 2022;12:877635. PubMed Central PMCID: PMC9676436.
Villagomez FR, Lang J, Rosario FJ, Nunez-Avellaneda D, Webb P, Neville M, Woodruff ER, Bitler BG. Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei. Cancer Res Commun. 2024 Jul 1;4(7):1625-1642. PubMed Central PMCID: PMC11218812.
Villagomez F, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick H, Webb P, Nephew K, Neville M, Woodruff E, Bitler B. Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Cancer Research Communications. 2025 January 01; 5(1):39-53. 2025 January; 5(1):39-53. doi: 10.1158/2767-9764.CRC-24-0558.
Asby SC, Thompson LE, Goedken M, Lucia SM, Dominguez AT, Kar A, Pitts TM, Kiseljak-Vassiliades K, Lang J, Aleksunes LM, Joy MS. Pathological findings of immunotherapy-induced nephrotoxicity in a humanized immune system mouse model. Kidney Int. 2025 Feb 6; PubMed PMID: 39922378
Tentler J, Lang J, Capasso A, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Hartman SJ, Yacob BW, Gittleman B, Pitts TM, Pelanda R, Eckhardt SG and Diamond JR. 2020. RX-5092, a Novel b-catenin Modulator, Potentiates the Efficacy of Immune Checkpoint Inhibitors in Preclinical Models of Triple-negative Breast Cancer. BMC Cancer 20(10):1063. PMID: 33148223.

Alves da Costa T, Peterson, J, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM and Pelanda R. 2021. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2021570118. doi: 10.1073/pnas.2021570118. PMID: 33850015.
Alves da Costa, T, Lang J, Torres RM and Pelanda R. 2019. The development of human immune system mice and their use to study tolerance and autoimmunity. J Transl Autoimmun. 2:100021. PMID: 32743507.
Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM and Pelanda R. 2017. Replacing mouse BAFF with human BAFF increases human B cell numbers but not B cell maturation in humanized mice. Blood Advances. 1:2729-2741. PMID: 29296925.
Lang J, Ota T, Kelly M, Strauch, P, Freed BM, Torres RM, Nemazee D and Pelanda R. 2016. Receptor Editing and genetic variability in human autoreactive B cells. J Exp Med 213(1):93-108. PMID: 26694971.
Lang J and Pelanda R. 2014. Human B-Cell Development in a Mouse Environment in Poluektova LY, Garcia-Martinez JV, Koyanagi Y, Manz MG, Tager AM, (Eds), Humanized Mice for HIV Research (pp141-152). New York, Heidelberg, Dordrecht, London: Springer. ISBN 978-1-4939-1654-2.
Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. 2013. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 190(5):2090-101. PMID: 23335750.

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