Research

The Department of Surgery at CU has a rich history of research with fundamental discoveries in basic, translational and clinical sciences that have shaped the practice of surgery and medicine regionally, nationally and around the globe. At UC Denver, we are continually examining our clinical outcomes and looking for ways that our experience can contribute to medical knowledge and the advancement of the care of patients with vascular disease.

Vascular Surgery participates in several landmark clinical research trials supported by industry and the National Institutes of Health. These projects focus on aortic and acute limb pathologies and investigate emerging device technologies and vascular/endovascular techniques.

Vascular Surgery participates in the SVS-PSO Vascular Quality Initiative, a national registry of vascular surgical outcome data used for both quality and vascular surgical outcomes. Tracked procedures include carotid endarterectomy and stent placement, infra-inguinal bypass and peripheral vascular interventions, and open and endovascular aortic repairs, along with thoracic aortic/ complex endovascular aneurysm repairs.

The Vascular Surgery faculty also participates in the Surgical Outcomes and Applied Research initiative (SOAR), a collaboration between the Department of Surgery and the Adult and Child Center for Health Outcomes Research and Delivery Science (ACCORDS). Please visit the SOAR website for more information.

Vascular Surgery utilizes the research services of the Colorado Prevention Center (CPC), an academically led clinical research organization which has responded to the demands of a fast-paced clinical research industry and competitive market for over two decades. The CPC offers full-service clinical trial design, oversight, and management with rapid access to key opinion leaders in a variety of therapeutic areas. These individuals are on the cutting edge of scientific, clinical and regulatory developments. Many of CPC's leadership team have chaired and/or served on FDA advisory committees.

The Division of Vascular Surgery also devotes its research efforts to clinical and outcomes research through multidisciplinary collaborations with the Departments of Cardiology, Cardiovascular Surgery, Vascular Medicine, Interventional Radiology, and Bioengineering. There are numerous opportunities for the vascular surgery fellow and surgical residents to participate in research. With all of the medical sciences concentrated on the Anschutz Medical Campus, collaboration between scientists and physician scientists is nearly effortless.

For questions, please contact Darci Adams, Business Services Program Director, at (303) 724-2697.



Publications


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2019

Anti-coagulation management in pediatric traumatic vascular injuries. Shahi N, Phillips R, Meier M, Nehler M, Jacobs D, Recicar J, Bensard D, Moulton S. J Pediatr Surg. 2019 Oct 31. pii: S0022-3468(19)30744-4. doi: 10.1016/j.jpedsurg.2019.10.009. PMID: 31732119

Stent-Graft Length Is Associated with Decreased Patency in Treatment of Central Venous Stenosis in Hemodialysis Patients. Boutrous ML, Alvarez AC, Okoye OT, Laws JC, Jacobs DL, Smeds MR. Ann Vasc Surg. 2019 Aug;59:225-230. doi: 10.1016/j.avsg.2019.01.024. Epub 2019 Apr 19. PMID: 31009722

The evolution of transcarotid artery stenting with flow reversal. Malgor RD, Shah RM. J Vasc Bras. 2019 Oct 23;18:e20190105. doi: 10.1590/1677-5449.190105. No abstract available. PMID: 31692817

Are Risks Reduced by Delaying Thoracic Endovascular Aneurysm Repair in Patients with Acute Type B Dissection: Who Can Wait? Malgor RD, Verhoeven E, Katsargyris A. Eur J Vasc Endovasc Surg. 2019 Nov;58(5):639-640. doi: 10.1016/j.ejvs.2019.07.020. Epub 2019 Sep 26. No abstract available. PMID: 31500992

Mortality in open abdominal aortic surgery in patients with morbid obesity. Khorgami Z, Sclabas GM, Aminian A, Lau PJ, Chow GS, Malgor RD, Howard CA, Taubman KE. Surg Obes Relat Dis. 2019 Jun;15(6):958-963. doi: 10.1016/j.soard.2019.03.044. Epub 2019 Apr 4. PMID: 31097382

Rescue of proximal failure of endovascular abdominal aortic aneurysm repair with standard and fenestrated grafts. Marques de Marino P, Malgor RD, Verhoeven EL, Katsargyris A. J Cardiovasc Surg (Torino). 2019 Apr;60(2):159-166. doi: 10.23736/S0021-9509.19.10872-5. Epub 2019 Jan 18. PMID: 30665286

Effects of canagliflozin on amputation risk in type 2 diabetes: the CANVAS Program. Matthews DR, Li Q, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Desai M, Hiatt WR, Nehler M, Fabbrini E, Kavalam M, Lee M, Neal B. Diabetologia. 2019 Jun;62(6):926-938. doi: 10.1007/s00125-019-4839-8. Epub 2019 Mar 12. PMID: 30868176

Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy. Pastori D, Eikelboom JW, Anand SS, Patel MR, Tanguay JF, Ricco JB, Debus ES, Mazzolai L, Bauersachs R, Verhamme P, Bosch J, Nikol S, Nehler M, Aboyans V, Violi F. Thromb Haemost. 2019 Apr;119(4):576-585. doi: 10.1055/s-0039-1678527. Epub 2019 Jan 31. Review. PMID: 30703812

Current issues and future directions for vascular surgery training from the results of the 2016-2017 and 2017-2018 Association of Program Directors in Vascular Surgery annual training survey. Hekman KE, Wohlauer MV, Magee GA, Shokrzadeh CL, Brown KR, Carsten CG 3rd, Chaer R, Jazaeri O, Lee AM, Singh N, Coleman DM. J Vasc Surg. 2019 May 27. pii: S0741-5214(19)30495-1. doi: 10.1016/j.jvs.2019.02.050. [Epub ahead of print] PMID: 31147127

Evolving Trends in Insurance Coverage of Vascular Surgery Patients in Academic Practice. Dua A, Rothenberg K, Srivastava G, Brown K, Lewis B, Rossi P, Seabrook G, Malinowski M, Wohlauer M, Lee CJ. Ann Vasc Surg. 2019 May;57:170-173. doi: 10.1016/j.avsg.2018.09.011. Epub 2018 Nov 27. PMID: 30500649

Diagnostic workup and endovascular treatment of popliteal artery trauma. Lee CJ, Loo R, Wohlauer MV, Patel PJ.

Vasa. 2019 Jan;48(1):65-71. doi: 10.1024/0301-1526/a000756. Epub 2018 Oct 17. Review. PMID: 30326793

The Vascular Quality Initiative 30-day stroke/death risk score calculator after transfemoral carotid artery stenting. Dakour-Aridi H, Faateh M, Kuo PL, Zarkowsky DS, Beck A, Malas MB. J Vasc Surg. 2019 Sep 13. pii: S0741-5214(19)31664-7. doi: 10.1016/j.jvs.2019.05.051. PMID: 31526692

A multi-institutional experience in vascular Ehlers-Danlos syndrome diagnosis. Shalhub S, Byers PH, Hicks KL, Coleman DM, Davis FM, De Caridi G, Weaver KN, Miller EM, Schermerhorn ML, Shean K, Oderich G, Ribeiro M, Nishikawa C, Charlton-Ouw K, Behrendt CA, Debus ES, von Kodolitsch Y, Zarkowsky D, Powell RJ, Pepin M, Milewicz DM, Regalado ES, Lawrence PF, Woo K. J Vasc Surg. 2019 Jul 25. pii: S0741-5214(19)31330-8. doi: 10.1016/j.jvs.2019.04.487. [Epub ahead of print] PMID: 31353273

Elective infrainguinal lower extremity bypass for claudication is associated with high postoperative intensive care utilization. Alshaikh HN, Hicks CW, DiBrito SR, Zarkowsky DS, Siracuse JJ, Malas MB. J Vasc Surg. 2019 Jun;69(6):1863-1873.e1. doi: 10.1016/j.jvs.2018.08.182. PMID: 31159987

A multi-institutional experience in the aortic and arterial pathology in individuals with genetically confirmed vascular Ehlers-Danlos syndrome. Shalhub S, Byers PH, Hicks KL, Charlton-Ouw K, Zarkowsky D, Coleman DM, Davis FM, Regalado ES, De Caridi G, Weaver KN, Miller EM, Schermerhorn ML, Shean K, Oderich G, Ribeiro M, Nishikawa C, Behrendt CA, Debus ES, von Kodolitsch Y, Powell RJ, Pepin M, Milewicz DM, Lawrence PF, Woo K. J Vasc Surg. 2019 Nov;70(5):1543-1554. doi: 10.1016/j.jvs.2019.01.069. Epub 2019 May 21. PMID: 31126764

Predictors of in-hospital adverse events after endovascular aortic aneurysm repair. Nejim B, Zarkowsky D, Hicks CW, Locham S, Dakour Aridi H, Malas MB. J Vasc Surg. 2019 Jul;70(1):80-91. doi: 10.1016/j.jvs.2018.10.093. Epub 2019 Feb 15. PMID: 30777687

Extending endovascular aneurysm repair to more patients without better outcomes. Zarkowsky DS, Hicks CW, Bostock IC, Malas MB, Goodney PP. J Vasc Surg. 2019 May;69(5):1412-1420.e1. doi: 10.1016/j.jvs.2018.08.170. Epub 2018 Nov 26.

PMID: 30497862

Fenestrated aortic endograft branching with Gore VBX poses failure risk from delayed-onset branch kinking. Yi JA, Kuwayama DP. J Vasc Surg Cases Innov Tech. 2018 Dec 31;5(1):18-21. doi: 10.1016/j.jvscit.2018.08.011. eCollection 2019 Mar. PMID: 30619985

Fourth Time Redo Common Femoral Vein Reconstruction with a Novel Hybrid Technique. Plotkin A, Bartley MG, Bowser KE, Yi JA, Jazaeri O, Magee GA. Ann Vasc Surg. 2019 May;57:49.e7-49.e11. doi: 10.1016/j.avsg.2018.10.006. Epub 2018 Nov 23. PMID: 30476613

Inferior Vena Cava Filter Resulting in Perforation and Massive Retroperitoneal Hematoma Presenting as Acute Onset of Lower Extremity Weakness. Magee GA, Bartley MG, Plotkin A, Yi JA, Glebova NO. Ann Vasc Surg. 2019 May;57:48.e13-48.e17. doi: 10.1016/j.avsg.2018.09.002. Epub 2018 Sep 12. PMID: 30218834

Claims Variability in Charges and Payments for Common Open and Endovascular Procedures. Yi JA, Bronsert M, Glebova NO. Ann Vasc Surg. 2019 Jan;54:40-47.e1. doi: 10.1016/j.avsg.2018.08.071. Epub 2018 Sep 11. PMID: 30217701

2018

Association of variant arch anatomy with type B aortic dissection and hemodynamic mechanisms. Shalhub S, Schäfer M, Hatsukami TS, Sweet MP, Reynolds JJ, Bolster FA, Shin SH, Reece TB, Singh N, Starnes BW, Jazaeri O. J Vasc Surg. 2018 May 24. pii: S0741-5214(18)30888-7. doi: 10.1016/ j.jvs.2018.03.409. [Epub ahead of print] PMID: 29804742

Isolated iliac vascular injuries and outcome of repair versus ligation of isolated iliac vein injury. Magee GA, Cho J, Matsushima K, Strumwasser A, Inaba K, Jazaeri O, Fox CJ, Demetriades D. J Vasc Surg. 2018 Jan;67(1):254-261. doi: 10.1016/j.jvs.2017.07.107. PMID: 29268917

Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease. Schäfer M, Kheyfets VO, Barker AJ, Stenmark K, Hunter KS, McClatchey PM, Buckner JK, Reece TB, Jazaeri O, Fenster BE. J Vasc Surg. 2018 Jul; 68(1):246-253. doi: 10.1016/j.jvs.2017.06.110. Epub 2017 Oct 3. PMID: 28986100

Letters of Recommendation: How Do They Fit Into the Modern Application? Nehler M. J Grad Med Educ. 2018 Jun; 10(3):267-268. doi: 10.4300/JGME-D-18-00258.1. No abstract available. PMID: 29946381

Examination of Nondesignated Preliminary Surgery Residents Recruited Since the Inception of Supplementary Offer and Acceptance Program: Lessons Learned From a Large Academic Program. Albuja-Cruz M, Travis C, Benge M, Caufield B, Nehler M. J Surg Educ. 2018 Mar - Apr;75(2):294-298. doi: 10.1016/j.jsurg.2017.08.008. Epub 2017 Sep 5. PMID: 28886935

Authors' Reply: Are American Surgical Residents Prepared for Humanitarian Deployment? A Comparative Analysis of Resident and Humanitarian Case Logs. Kuwayama D. World J Surg. 2018 Jun 26. doi: 10.1007/s00268-018-4713-8. [Epub ahead of print] No abstract available. PMID: 29946787

Successful use of continuous vasodilator infusion to treat critical vasospasm threatening a distal bypass. Magee GA, Plotkin A, Yi JA, Bowser KE, Kuwayama DP. J Vasc Surg Cases Innov Tech. 2018 Feb 27; 4(1):58-62. doi: 10.1016/j.jvscit.2017.12.003. eCollection 2018 Mar. PMID: 29725664

Multiple Strokes Associated With Elongation of the Hyoid Bone. Ludt C, Leppert M, Jones A, Song J, Kuwayama D, Pastula DM, Poisson S. Neurohospitalist. 2018 Jan; 8(1):35-37. doi: 10.1177/1941874417706220. Epub 2017 Apr 28. PMID: 29276562

The Colorado Humanitarian Surgical Skills Workshop: A Cadaver-Based Workshop to Prepare Residents for Surgery in Austere Settings. Lin Y, Mukhopadhyay S, Meguid RA, Kuwayama DP. J Surg Educ. 2018 Mar - Apr; 75(2):383-391. doi: 10.1016/j.jsurg.2017.08.009. Epub 2017 Aug 31. PMID: 28864266

Are American Surgical Residents Prepared for Humanitarian Deployment? : A Comparative Analysis of Resident and Humanitarian Case Logs. Lin Y, Dahm JS, Kushner AL, Lawrence JP, Trelles M, Dominguez LB, Kuwayama DP. World J Surg. 2018 Jan; 42(1):32-39. doi: 10.1007/s00268-017-4137-x. PMID: 28779383

2017

Morbidity of endovascular abdominal aortic aneurysm repair is directly related to diameter. Overbey DM, Glebova NO, Chapman BC, Hosokawa PW, Eun JC, Nehler MR. J Vasc Surg. 2017 Oct;66(4):1037-1047.e7. doi: 10.1016/ j.jvs.2017.01.058. Epub 2017 Apr 19. PMID: 28433338

Association of General Surgery Resident Remediation and Program Director Attitudes with Resident Attrition. Schwed AC, Lee SL, Salcedo ES, Reeves ME, Inaba K, Sidwell RA, Amersi F, Are C, Arnell TD, Damewood RB, Dent DL, Donahue T, Gauvin J, Hartranft T, Jacobsen GR, Jarman BT, Melcher ML, Mellinger JD, Morris JB, Nehler M, Smith BR, Wolfe M, Kaji AH, de Virgilio C. JAMA Surg. 2017 Dec 1;152(12):1134-1140. doi: 10.1001/jamasurg.2017.2656. PMID: 28813585

A Fourteen-Year Experience with Vascular Anomalies Encountered during Transaxillary Rib Resection for Thoracic Outlet Syndrome. Yi JA, Johnston RJ, Nehler MR, Gibula DR, Alix K, Glebova NO, Brantigan CO. Ann Vasc Surg. 2017 Apr; 40:105-111. doi: 10.1016/j.avsg.2016.08.037. Epub 2016 Dec 12. PMID: 27979572

Concurrent hydrocelectomy during inguinal herniorrhaphy is a risk factor for complications and reoperation: data from rural Haiti. Kuwayama DP, Augustin J. Hernia. 2017 Oct; 21(5):759-765. doi: 10.1007/s10029-017-1636-5. Epub 2017 Aug 10. PMID: 28799117

Choosing Surgery for Neurogenic TOS: The Roles of Physical Exam, Physical Therapy, and Imaging. Kuwayama DP, Lund JR, Brantigan CO, Glebova NO. Diagnostics (Basel). 2017 Jun 23; 7(2). pii: E37. doi: 10.3390/diagnostics7020037. Review. PMID: 28644402

2016

Treatment of Aortoiliac Occlusive Disease with the Endologix AFX Unibody Endograft. Maldonado TS, Westin GG, Jazaeri O, Mewissen M, Reijnen MM, Dwivedi AJ, Garrett HE Jr, Dias Perera A, Shimshak T, Mantese V, Smolock CJ, Arthurs ZM. Eur J Vasc Endovasc Surg. 2016 Jul; 52(1):64-74. doi: 10.1016/j.ejvs.2016.04.003. Epub 2016 May 6. PMID: 27162000

Drivers of readmissions in vascular surgery patients. Glebova NO, Bronsert M, Hammermeister KE, Nehler MR, Gibula DR, Malas MB, Black JH, Henderson WG. J Vasc Surg. 2016 Jul; 64(1):185-194.e3. doi: 10.1016/j.jvs.2016.02.024. Epub 2016 Mar 30. PMID: 27038838

Contributions of planned readmissions and patient comorbidities to high readmission rates in vascular surgery patients. Glebova NO, Bronsert M, Hicks CW, Malas MB, Hammermeister KE, Black JH 3rd, Nehler MR, Henderson WG. J Vasc Surg. 2016 Mar; 63(3):746-55.e2. doi: 10.1016/j.jvs.2015.09.032. PMID: 26916584

Using satellite imagery and GPS technology to create random sampling frames in high risk environments. Lin Y, Kuwayama DP. Int J Surg. 2016 Aug; 32:123-8. doi: 10.1016/j.ijsu.2016.06.044. Epub 2016 Jul 5. PMID: 27392719

2015

The Contemporary Safety and Effectiveness of Lower Extremity Bypass Surgery and Peripheral Endovascular Interventions in the Treatment of Symptomatic Peripheral Arterial Disease. Tsai TT, Rehring TF, Rogers RK, Shetterly SM, Wagner NM, Gupta R, Jazaeri O, Hedayati N, Jones WS, Patel MR, Ho PM, Go AS, Magid DJ. Circulation. 2015 Nov 24; 132(21):1999-2011. doi: 10.1161/CIRCULATIONAHA.114.013440. Epub 2015 Sep 11. PMID: 26362632

Anatomic runoff score predicts cardiovascular outcomes in patients with lower extremity peripheral artery disease undergoing revascularization. Jones WS, Patel MR, Tsai TT, Go AS, Gupta R, Hedayati N, Ho PM, Jazaeri O, Rehring TF, Rogers RK, Shetterly SM, Wagner NM, Magid DJ. Am Heart J. 2015 Aug; 170(2):400-8. doi: 10.1016/j.ahj.2015.04.026. Epub 2015 May 2. PMID: 26299239

Vascular injury is associated with increased mortality in winter sports trauma. Eun JC, Bronsert M, Hansen K, Moulton SL, Jazaeri O, Nehler M, Greenberg JI. Ann Vasc Surg. 2015 Jan; 29(1):109-13. doi: 10.1016/j.avsg.2014.10.003. Epub 2014 Oct 31. PMID: 25449983

Measures to reduce unplanned readmissions after vascular surgery. Eun JC, Nehler MR, Black JH 3rd, Glebova NO. Semin Vasc Surg. 2015 Jun; 28(2):103-11. doi: 10.1053/j.semvascsurg.2015.09.002. Epub 2015 Sep 8. Review. PMID: 26655054

Drug-coated balloons to improve femoropopliteal artery patency: Rationale and design of the LEVANT 2 trial. Jaff MR, Rosenfield K, Scheinert D, Rocha-Singh K, Benenati J, Nehler M, White CJ. Am Heart J. 2015 Apr; 169(4):479-85. doi: 10.1016/j.ahj.2014.11.016. Epub 2014 Dec 20. PMID: 25819854

Computed tomography-guided reoperation for neurogenic thoracic outlet syndrome. Greenberg JI, Alix K, Nehler MR, Johnston RJ, Brantigan CO. J Vasc Surg. 2015 Feb; 61(2):469-74. doi: 10.1016/j.jvs.2014.07.008. Epub 2014 Aug 15. PMID: 25135877