Publications

2019

  • Smith A.L., Weissbart S.J, Hartigan S.M., Bilello M., Newman D.K., Wein A.J., Malykhina A.P., Erus G., Fan Y., Association Between Urinary Symptom Severity and White Matter Plaque Distribution in Women with Multiple Sclerosis. Neurourol. Urodyn, 2019 Nov 6. doi:10.1002/nau.24206. PMID: 31691357
  • Lee S., Nedumaran B., Hypolite J., Caldwell B., Rudolph M., Malykhina A.P. Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis. Sci Rep. 2019 Jul 26;9(1):10869. PMID: 31350464.
  • Iguchi N., Donmez M.I.,Carrasco A., Pineda R.H., Wilcox D.T. Malykhina A.P., Cost N. Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F197-F206. PMID:31066574.
  • Pineda R.H., Hypolite J., Lee S., Carrasco A., Iguchi N., Meacham R.B., Malykhina A.P. Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel. BMC Urol. 2019 May 21;19(1):40. PMID:31113422
  • Xin AX, Pan X.-Q, Meacham R.B., Malykhina A.P. The Expression of Transcription Factors MeCP2 and CREB Is Modulated in Inflammatory Pelvic Pain. Front System Neurosci. 2019 Jan 11;12:69. eCollection 2018. PMID:30687029
  • Nedumaran B., Pineda R.H., Rudra P., Lee S., Malykhina A.P. Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans. Neurourol Urodyn. 2019 Jan;38(1):144-150. PMID: 30350878.

2018

  • Iguchi N., Malykhina A.P., Wilcox D.T. Early life voiding dysfunction leads to long-term lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder. Am J Physiol Renal Physiol 2018 Nov 1;315(5):F1320-F1328. PMID: 30089034

2017

  • Malykhina A.P. How the brain controls urination. Elife 2017,Dec 4;6. pii:e33219. doi:10.7554/ eLife.33219. PMID: 29199949
  • Lee S., Carrasco A., Meacham R.B., Malykhina A.P. Transurethral Instillation Procedure in Adult Male Mouse. J Vis Exp. 2017 Nov 2;(129). PMID: 29155777.
  • Nedumaran B., Rudra P., Gaydos J., Kumar S., Meacham R.B., Burnham E.L., Malykhina A.P. Impact of regular cannabis use on biomarkers of lower urinary tract function. Urology. 2017 Nov;109:223.e9-223.e16. PMID: 28827195.
  • Iguchi N., Dönmez M., Malykhina A.P., Wilcox D.T. Preventative effects of a HIF inhibitor, 17-DMAG on partial bladder outlet obstruction-induced bladder dysfunction. Am J Physiol Renal Physiol. 2017 Nov 1;313(5):F1149-F1160. PMID:28768664.
  • Pineda R.H., Nedumaran B., Hypolite J., Pan X.-Q., Wilson S., Meacham R.B., Malykhina A.P. Altered expression and modulation of the two-pore domain (K2P) mechano-gated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol 2017 Aug 1;313(2):F535-F546. PMID: 28539337.
  • Lee S., Malykhina A.P. Neuro-tracing approach to study kidney innervation: a technical note. Kidney Res Clin Pract. Mar;36(1):86-94. PMID: 28393001
  • Richter H.E., Moalli P., Amundsen C.L., Malykhina A.P., Wallace D., Rogers R., Myers D., Paraiso M., Albo M., Shi H., Nolen T., Wallace D., Meikle S., Word R.A. Urinary Biomarkers in Women with Refractory Urgency Urinary Incontinence Randomized to Sacral Neuromodulation versus OnabotulinumtoxinA Compared to Controls. J Urol., Jan 13: S0022-5347(17)30063-0. PMID: 28089729.
  • Pennycuff J.F., Schutte S., Hudson C., Karp D., Malykhina A.P., Northington G.M. Urinary Neurotrophic Peptides in Postmenopausal Women with and without Overactive Bladder. Neurourol Urodyn, 2017 Mar;36(3):740-744. PMID: 27062604.
  • Malykhina A.P., Brodie K.E., Wilcox D.T. Genitourinary and gastrointestinal co-morbidities in children: role of neural circuits in regulation of visceral function. J Ped Urol , 2017, Jun 15: S1477-5131(16)30104-8. Review. PMID: 28392009.

2016

  • Smith AL, Hantsoo L, Malykhina AP, File DW, Valentino R, Wein AJ, Sammel MD, Epperson CN. Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder. Int Urogynecol J., 2016, 27(9):1383-91. PMID: 26942596.
  • Weissbart S.J., Pechersky D., Malykhina A., Bavaria T., Parillo L., Arya L.A., Bilello M., Wein A.J., Smith A.L. The impact of pontine disease on lower urinary tract symptoms in patients with multiple sclerosis. Neurourol Urodyn, 2016, Jan 6. doi: 10.1002/nau.22953. PMID: 26741487.
  • Iguchi N., Malykhina A.P., Wilcox D.T. Inhibition of hypoxia-inducible factors reduces bladder hypertrophy and improves bladder function in murine model of partial bladder outlet obstruction. J Urol, 2016, Feb 26. pi: S0022-5347(15) 04523-1. PMID: 26926557.

2015

  • Hypolite J.A., Malykhina A.P. Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology. BMC Urol, 2015, Nov 4;15(1):110. PMID:26538012.
  • Hypolite J.A., Chang S., Wein A.J., Chacko S., Malykhina A.P. Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neurogenic and myogenic mechanisms. BMC Urol.,2015, Apr 21;15(1):34. PMID: 25896919.
  • Andy U.U., Malykhina A., Harvi H.S., Colavita K, Whitmore K, Arya L.A.. Clinical and Biochemical Evidence of Neurogenic Inflammation in Women with Urinary Urgency. J of Minim Invas Gynec, 2015, 22(3):S21-22.