Project 2:

CNP-miR146a rescues lung function following Acute Lung Injury (ALI) and stops the development of Acute Respiratory Distress Syndrome (ARDS)

ALI in its most severe form, ARDS, is to date the most life-threatening complication reported from COVID-19. Early data suggest that more than 40% of individuals hospitalized for severe and critical COVID-19 developed ARDS and over 50% of those diagnosed died from the disease. While the etiology of ALI is multifactorial, a central pathogenic feature of the progression to ARDS is a persistent activation of inflammation and oxidative stress. In a bleomycin-induced model of ALI, we found that one-time administration of CNP-miR146a prevents inflammation and fibrosis, and improves pulmonary mechanics.

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