Project 1:

CNP-miR146a, a novel treatment that corrects impaired diabetic wound healing

We have designed a novel cerium oxide nanoparticles (CNPs) that possess ROS scavenging properties and have conjugated them with a miR-146a mimetic, to target both oxidative stress/ROS and pro-inflammatory signaling. Our studies have shown that local treatment of the diabetic wound with CNP-miR146a conjugate resulted in reduced time to wound healing with increased strength and elasticity in a murine model. This was further validated in a porcine model where treatment with CNP-miR146a resulted in reduced time to wound healing.

Project 1, Figure 1
Project 1, Figure 2