Lab Overview

The Krappitz Lab investigates the molecular mechanisms underlying autosomal-dominant polycystic kidney disease (ADPKD), with a focus on therapeutic approaches informed by the group’s published work. The lab has contributed to establishing both chaperone-based strategies and gene-editing approaches in PKD, demonstrating how proteostasis correction and base editing can stabilize polycystin function and improve cystic outcomes in experimental models. Current efforts continue to integrate mechanistic discovery with translational development to advance targeted therapies for PKD.