Idiopathic scoliosis (IS) is the most common deformity of the spine in children, with an estimated annual cost of over $3 billion per year. Individuals with IS face lifelong issues, including cosmetic deformity, bracing, and surgery, with females at the greatest risk for severe disease. Family history is a known risk factor for IS, but the genetic causes of the disease are not well understood. We are currently using next-generation sequencing coupled to functional models (animal and cell culture) to discover new genetic variants important to the development of IS. We are also interested in whether tissues relevant to IS— for example, bone and cartilage— harbor transcriptional differences between IS and control individuals. In separate projects, our lab is currently analyzing the transcriptomes of different tissues from IS individuals via RNA sequencing. We believe that these projects will help to discover new genetic regions important to IS, shedding much needed light on the disease process, advancing diagnostics, and paving the way for novel therapies.