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Department of Orthopedics

School of Medicine

Welcome to Miller Scoliosis Lab

Lab Director, Nancy Hadley Miller, M.D., M.S.

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    Nancy Hadley Miller, M.D., M.S.

    Nancy Hadley Miller, M.D., M.S.

    Professor of Orthopedics

    Welcome to Miller Scoliosis Lab

    Idiopathic scoliosis (IS) is the most common deformity of the spine in children, with an estimated annual cost of over $3 billion per year. Individuals with IS face lifelong issues, including cosmetic deformity, bracing, and surgery, with females at the greatest risk for severe disease. Family history is a known risk factor for IS, but the genetic causes of the disease are not well understood. We are currently using next-generation sequencing coupled to functional models (animal and cell culture) to discover new genetic variants important to the development of IS. We are also interested in whether tissues relevant to IS— for example, bone and cartilage— harbor transcriptional differences between IS and control individuals. In separate projects, our lab is currently analyzing the transcriptomes of different tissues from IS individuals via RNA sequencing. We believe that these projects will help to discover new genetic regions important to IS, shedding much needed light on the disease process, advancing diagnostics, and paving the way for novel therapies.

     

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    Exome Sequencing

    Projects

    Exome Sequencing in Families with Idiopathic Scoliosis

    Our NIH R01 focuses on performing exome sequencing on 100 samples from our cohort of scoliosis families in an effort to discover variants suspected of causing the disease. We will carefully select affected and unaffected individuals from our pedigrees for the most statistical, genetic, and clinical relevance.

     

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    Publications

    NCBI Bibliography

    Select publications:

    1. Terhune EA, Monley AM, Cuevas MT, Wethey CI, Gray RS, Hadley-Miller N. Genetic animal modeling for idiopathic scoliosis research: history and considerations. Spine Deform. 2022 Sep;10(5):1003-1016. doi: 10.1007/s43390-022-00488-7. Epub 2022 Apr 16. PMID: 35430722.
    2. Carry PM, Terhune EA, Trahan GD, Vanderlinden LA, Wethey CI, Ebrahimi P, McGuigan F, Åkesson K, Hadley-Miller N. Severity of Idiopathic Scoliosis Is Associated with Differential Methylation: An Epigenome-Wide Association Study of Monozygotic Twins with Idiopathic Scoliosis. Genes (Basel). 2021 Jul 30;12(8). doi: 10.3390/genes12081191. PubMed PMID: 34440365; PubMed Central PMCID: PMC8391702.
    3. Terhune EA, Wethey CI, Cuevas MT, Monley AM, Baschal EE, Bland MR, Baschal R, Trahan GD, Taylor MRG, Jones KL, Hadley Miller N. Whole Exome Sequencing of 23 Multigeneration Idiopathic Scoliosis Families Reveals Enrichments in Cytoskeletal Variants, Suggests Highly Polygenic Disease. Genes (Basel). 2021 Jun 16;12(6). doi: 10.3390/genes12060922. PubMed PMID: 34208743; PubMed Central PMCID: PMC8235452.
    4. Terhune EA, Cuevas MT, Monley AM, Wethey CI, Chen X, Cattell MV, Bayrak MN, Bland MR, Sutphin B, Trahan GD, Taylor MRG, Niswander LA, Jones KL, Baschal EE, Antunes L, Dobbs M, Gurnett C, Appel B, Gray R, Hadley Miller N. Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Hum Mutat. 2021 Apr;42(4):392-407. doi: 10.1002/humu.24162. Epub 2021 Feb 7. PubMed PMID: 33382518; PubMed Central PMCID: PMC8049985.

     

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    Contact Us

    Miller Scoliosis Lab

    Mail Stop 8343
    Research Complex 1 North
    12800 E. 19th Avenue, Room 3107
    Aurora, CO 80045
    Office: 303-724-0357
    Nancy.Miller@childrenscolorado.org

    Orthopedics (SOM)

    CU Anschutz

    Academic Office One

    12631 East 17th Avenue

    4602

    Aurora, CO 80045


    303-724-2955

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