Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is the most prevalent form of spinal deformity, accounting for 80% of pediatric scoliosis and impacts 2-4% of children. AIS affects predominantly girls and is defined by a lateral spinal curvature, lacking a known neuromuscular cause or genetic origin. Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Identifying potential markers for curve progression in AIS will help in development of a diagnostic to better predict spinal curve progression.
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