GEMM provides full-service mouse genetic engineering support to researchers. We will help you select the best model for your research program, design and build any constructs and reagents, and produce live mouse models. The most popular requests are for CRISPR/Cas9 gene edited mice and classic gain of function mice. To date, we have created engineered alleles for knockouts, conditional knockouts, SNP knockins, tag and reported insertions, deletions of up to 300kb, duplications, and classic/BAC gain of function alleles. These novel mouse models have been made on a wide spectrum of genetic background strains, including but not limited to C57BL/6J, C57BL/6N, NOD, BALB/cJ, FVB/Crl, NSGS, various 129 substrains, collaborative cross strains, and on mice that are already genetically modified.
In addition, we have a robust breeding and genotyping program. We can breed new models to establish germline transmission and can also create cohorts for investigators. We provide strain cryopreservation, rederivation and rescue services, as well as cryostorage. Our services are available to outside institutions, nationally and internationally.
