B cells play a significant role in the pathogenesis of Type 1 Diabetes (T1D), with evidence suggesting they may have a greater impact in patients diagnosed at a young age. To explore this, Jessica Prendergast plans to utilize single-cell sequencing to analyze transcriptional profiles, antigen affinity, reactivity, and repertoire differences across B cell subsets in young-onset versus adult-onset T1D.

Discover how orally administered Ex-4 improves glucose tolerance without systemic absorption by targeting localized intestinal GLP-1 receptors. This presentation will unveil sex-specific differences in GLP-1R function, revealing that vagal GLP-1R mediates glucose-lowering effects in males but not females. These findings provide critical insights into the mechanisms of oral GLP-1 therapies and could inform personalized metabolic treatment strategies.

Please join us for a Research in Progress (RIP) seminar titled "Utilizing Ecological Momentary Assessment to Understand Barriers and Facilitators of Physical Activity in Youth at Risk for Type 2 Diabetes." Dr. Ana Gutierrez-Colina, Assistant Professor of Department of Human Development and Family Studies, Colorado State University, will share her innovative study employing Ecological Momentary Assessment (EMA) to capture real-time data on barriers and facilitators of physical activity in at-risk youth.

Fetal growth restriction (FGR) results in intrauterine β-cell failure and an increased risk of type 2 diabetes later in life, but the underlying mechanisms remain unknown. Dr. Alicia White’s groundbreaking research investigates these mechanisms, focusing on NFκB signaling adaptations in the pancreata of FGR fetuses.