Ludeman Family Seed Grant Recipient
Seed grant project title: Sex Differences in Microglial-lipoprotein Metabolism and Alzheimer's Disease Risk
Current research focus: Many neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease (AD) are more prevalent in women and have a marked impact on physical and mental health. Female sex is a major risk factor for late-onset AD, and females carrying the APOE4 gene are more likely to develop severe AD. Despite these well-known associations, the reason for this increased risk is unclear. Recent work from Dr. Bruce's laboratory has shown that females have enhanced fat and cholesterol metabolism in specialized brain cells, which may be detrimental in the presence of AD risk factors such as APOE4. This study will determine the mechanism by which APOE4 contributes to worse disease outcomes in females and will help guide how we treat females with AD, particularly APOE4 carriers.