Publications

2020

Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC (DT), Davila E (THI). Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol 1:306, 2020. PMID: 32533049 / PMC7293221

Guntupalli SR# (DT), Brennecke A, Behbakht K (DT), Tayebnejad A, Breed CA, Babayan LM, Cheng G, Ramzan AA, Wheeler LJ, Corr BR# (DT), Lefkowits C, Sheeder J, Matsuo K, Flink D. Safety and Efficacy of Apixaban vs Enoxaparin for Preventing Postoperative Venous Thromboembolism in Women Undergoing Surgery for Gynecologic Malignant Neoplasm: A Randomized Clinical Trial. JAMA Netw Open 6:e207410, 2020. PMID: 32589230 / PMC7320298

Hernandez AL, Young CD, Bian L, Weigel K, Nolan K, Frederick B, Han G, He G, Devon Trahan G, Rudolph MC, Jones KL (MCO), Oweida AJ, Karam SD (DT), Raben D (DT), Wang XJ (THI). PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. Clin Cancer Res 2020. PMID: 32139402 / PMC7299799

Kern JA (DT), Kim J, Foster DG, Mishra R, Gardner EE, Poirier JT, Rivard C, Yu H, Finigan JH, Dowlati A, Rudin CM, Tan AC (DT). Role of mTOR as an essential kinase in SCLC. J Thorac Oncol 2020. PMID: 32599072 / PMC7483946

Keysar SB, Gomes N, Miller B, Jackson BC, Le PN, Morton JJ, Reisinger J, Chimed TS, Gomez KE, Nieto C, Frederick B, Pronk GJ, Somerset HL, Tan AC (DT), Wang XJ (THI), Raben D (DT), Su TT (MCO), Jimeno A (DT). Inhibiting Translation Elongation with SVC112 Suppresses Cancer Stem Cells and Inhibits Growth in Head and Neck Squamous Carcinoma. Cancer Res 5:1183-1198, 2020. PMID: 31911553 / PMC7056512

Mukherjee N, Skees J, Todd KJ, West DA, Lambert KA, Robinson WA (DT), Amato CM, Couts KL, Van Gullick R, MacBeth M, Nassar K, Tan AC (DT), Zhai Z, Fujita M (THI), Bagby SM, Dart CR, Lambert JR, Norris DA (DT), Shellman YG# (THI). MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis 6:443, 2020. PMID: 32513939 / PMC7280535

Patel SG# (CPC), Ahnen DJ, Gumidyala A, Espinoza J, Nicklawsky A, Hu J, Smith D, Lowery J, Austin G, Cockburn M (CPC). Poor Knowledge of Personal and Familial Colorectal Cancer Risk and Screening Recommendations Associated with Advanced Colorectal Polyps. Dig Dis Sci 2020. PMID: 32144601 / PMC7513555

Pei S, Pollyea DA (DT), Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC (THI), Amaya ML, Inguva A, Winters A# (DT), Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A# (MCO), Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT (MCO). Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia. Cancer Discov 4:536-551, 2020. PMID: 31974170 / PMC7124979

Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D (CPC), Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs S, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD (DT), Robin TP. Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study. JAMA Oncol 2020. PMID: 32496550 / PMC7273318

Schreiber AR, Kar A, Goodspeed AE, Pozdeyev N, Somerset H, Raeburn CD, Tan AC, Leong S (DT), Wierman ME (DT), Kiseljak-Vassiliades K# (DT). Leptomeningeal Metastasis from Adrenocortical Carcinoma: A Case Report. J Endocr Soc 3:bvaa017, 2020. PMID: 32154490 / PMC7053406

Torkko K, Till C, Tangen CM, Goodman PJ, Song X, Schenk JM, Lucia MS (DT), Peters U, van Bokhoven A, Thompson IM, Neuhouser ML. Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial. Cancer Prev Res (Phila) 2020. PMID: 32102946 / PMC7272271

Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL (DT), Regan DP# (THI), D'Alessandro A# (MCO), Costello JC (THI), Patnaik S, Marugan J, Zhao R (MCO), Ford HL (THI). Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res12:2689-2702, 2020. PMID: 32341035 / PMC7510951

2019

Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D (DT), Serkova NJ (DT), Wang XJ (THI), Jimeno A (DT), Clambey ET (THI), Pasquale EB, Karam SD (DT). Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res 10:2722-2735, 2019. PMID: 30894369 / PMC6522285

Bonney S, Seitz S, Ryan CA, Jones KL (MCO), Clarke P, Tyler KL (MCO), Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. MBio4:2019. PMID: 31387911 / PMC6686045

Capasso A, Bagby SM, Dailey KL, Currimjee N, Yacob BW, Ionkina A, Frank JG, Kim DJ, George C, Lee YB, Benaim E, Gittleman B, Hartman SJ, Tan AC (DT), Kim J, Pitts TM, Eckhardt SG, Tentler JJ (DT), Diamond JR (DT). First-in-class phosphorylated-p68 inhibitor RX-5902 inhibits beta-catenin signaling and demonstrates anti-tumor activity in triple-negative breast cancer. Mol Cancer Ther 2019. PMID: 31488700 / PMC6825586

Capasso A, Bagby SM, Dailey KL, Currimjee N, Yacob BW, Ionkina A, Frank JG, Kim DJ, George C, Lee YB, Benaim E, Gittleman B, Hartman SJ, Tan AC (DT), Kim J, Pitts TM, Eckhardt SG, Tentler JJ (DT), Diamond JR (DT). First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer. Mol Cancer Ther 11:1916-1925, 2019. PMID: 31488700 / PMC6825586

Chen Y, Jones KL (MCO), Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P (MCO). Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia. Exp Hematol 37-42, 2019. PMID: 30315824 / PMC6472707

Das S, Idate R, Cronise KE, Gustafson DL (DT), Duval DL (THI). Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing. Mol Cancer Ther 8:1460-1471, 2019. PMID: 31175136 / PMC6679748

Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A# (MCO), Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K (MCO), Pietras E (THI), DeGregori J (THI), Rondina MT, Di Paola J (THI). TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood 2019. PMID: 31311815 / PMC6716075

Goodspeed A, Jean A, Costello JC (THI). A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. Eur Urol 2:242-250, 2019. PMID: 30414698 / PMC6339584

Greene LI, Bruno TC, Christenson JL, D'Alessandro A# (MCO), Culp-Hill R, Torkko K, Borges VF (THI), Slansky JE (THI), Richer JK (THI). A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. Mol Cancer Res 1:131-139, 2019. PMID: 30143553 / PMC6318037

Hinz TK, Kleczko EK, Singleton KR, Calhoun J, Marek LA, Kim J, Tan AC (DT), Heasley LE (THI). Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines. Mol Pharmacol 6:862-870, 2019. PMID: 31554698 / PMC7385532

Keith RL (CPC), Blatchford PJ, Merrick DT (CPC), Bunn PA Jr (DT), Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YE (CPC). A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers. Cancer Prev Res (Phila) 10:721-730, 2019. PMID: 31308004 / PMC6774885

Kessler BE, Mishall KM, Kellett MD, Clark EG, Pugazhenthi U, Pozdeyev N, Kim J, Tan AC (DT), Schweppe RE (MCO). Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene 14:2565-2579, 2019. PMID: 30531837 / PMC6450711

Korobeynikov V, Borakove M, Feng Y, Wuest WM, Koval AB, Nikonova AS, Serebriiskii I, Chernoff J, Borges VF (THI), Golemis EA, Shagisultanova E# (DT). Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Res Treat 2:369-382, 2019. PMID: 31254157 / PMC6661032

Landa I, Pozdeyev N, Korch C, Marlow LA, Smallridge RC, Copland JA, Henderson YC, Lai SY, Clayman GL, Onoda N, Tan AC (DT), Garcia-Rendueles MER, Knauf JA, Haugen BR (MCO), Fagin JA, Schweppe RE (MCO). Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies. Clin Cancer Res 10:3141-3151, 2019. PMID: 30737244 / PMC6522280

Ng TL, Yu H, Smith DE, Boyle TA, York ER, Leedy S, Gao D (CPC), Aisner DL (DT), Van Bokhoven A, Heasley LE (THI), Hirsch FR (DT), Camidge DR (DT). Preselection of Lung Cancer Cases Using FGFR1 mRNA and Gene Copy Number for Treatment With Ponatinib. Clin Lung Cancer 1:e39-e51, 2019. PMID: 30297175 / PMC6339510

Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC (THI), Ghosh D (CPC), DeGregori J (THI), Espinosa JM (MCO), Ford HL (THI). SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. Cancer Res 4:720-734, 2019. PMID: 30606720 / PMC6586234

Osborne DG, Domenico J, Luo Y, Reid AL, Amato C, Zhai Z, Gao D (CPC), Ziman M, Dinarello CA (THI), Robinson WA (DT), Fujita M (THI). Interleukin-37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome. Mol Carcinog 9:1670-1679, 2019. PMID: 31099111 / PMC6692223

Pacheco JM, Gao D (CPC), Smith D, Purcell T (DT), Hancock M, Bunn P (DT), Robin T, Liu A (DT), Karam S (DT), Gaspar L, Kavanagh B (DT), Rusthoven C, Aisner D (DT), Doebele R (MCO), Camidge DR (DT). Natural History and Factors Associated with Overall Survival in Stage IV ALK-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol 4:691-700, 2019. PMID: 30599201 / PMC7310567

Panigrahi GK, Praharaj PP, Kittaka H, Mridha AR, Black OM, Singh R, Mercer R, van Bokhoven A, Torkko KC, Agarwal C (CPC), Agarwal R (CPC), Abd Elmageed ZY, Yadav H, Mishra SK, Deep G. Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients. Cancer Med3:1110-1123, 2019. PMID: 30623593 / PMC6434210

Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D (CPC), Collins C, Paola JTD, D'Alessandro A# (MCO), DeGregori J (THI). Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.Mol Cancer Res 6:1351-1364, 2019. PMID: 30808730 / PMC6548670

Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A# (MCO), Degala GD, Shin J, Tan AC (DT), Cittelly DM (THI), Lambert JR, Richer JK (THI). Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res1:30-41, 2019. PMID: 30213797 / PMC6318067

Saltzman AF, Smith DE, Gao D (CPC), Ghosh D (CPC), Amini A, Aldrink JH, Dasgupta R, Gow KW, Glick RD, Ehrlich PF, Cost NG. How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor. J Pediatr Surg 11:2331-2335, 2019. PMID: 31255328 / PMC6881092

Samson JM, Ravindran Menon D, Smith DE, Baird E, Kitano T, Gao D (CPC), Tan AC (DT), Fujita M (THI). Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes. Chem Biol Interact 108822, 2019. PMID: 31580832 / PMC6916670

Tobin RP, Jordan KR, Kapoor P, Spongberg E, Davis D, Vorwald VM, Couts KL, Gao D (CPC), Smith DE, Borgers JSW, Robinson S, Amato C, Gonzalez R (DT), Lewis KD (DT), Robinson WA (DT), Borges VF (THI), McCarter MD (THI). IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients. Front Oncol 1223, 2019. PMID: 31781510 / PMC6857649

Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC (THI), Clambey ET (THI), Costello JC (THI), Korman AJ, Theodorescu D (DT). Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. Sci Adv 2:eaav2437, 2019. PMID: 30801016 / PMC6382401

Tufa DM, Yingst AM, Shank T, Shim S, Trahan GD, Lake J, Woods R, Jones KL (MCO), Verneris MR (THI). Transient Expression of GATA3 in Hematopoietic Stem Cells Facilitates Helper Innate Lymphoid Cell Differentiation.Front Immunol 510, 2019. PMID: 30949172 / PMC6438154

Washino S, Rider LC, Romero L, Jillson LK, Affandi T, Ohm AM, Lam ET (DT), Reyland ME (MCO), Costello JC (THI), Cramer SD (MCO). Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination. Mol Cancer Res 10:1985-1998, 2019. PMID: 31300540 / PMC7266379

Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K (DT), Bitler BG# (DT). Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Clin Epigenetics 1:165, 2019. PMID: 31775874 / PMC6882350

Wheeler LJ, Watson ZL, Qamar L, Yamamoto TM, Sawyer BT, Sullivan KD# (MCO), Khanal S, Joshi M, Ferchaud-Roucher V, Smith H, Vanderlinden LA, Brubaker SW, Caino CM# (MCO), Kim H, Espinosa JM (MCO), Richer JK (THI), Bitler BG# (DT). Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. iScience 474-491, 2019. PMID: 31437751 / PMC6710300

Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM (THI), Joglar AM, Brennecke EP, Wilson H, Behbakht K (DT), Sikora MJ# (THI), Bitler BG# (DT). Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Mol Carcinog 10:1770-1782, 2019. PMID: 31219654 / PMC7537108

2018

Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA.  ALK Inhibitor response in melanomas expressing EML4-ALK fusions and alternate ALK isoforms.  Mol Cancer Ther 17: 222-231, 2018.  PMID: 29054983 / PMC5752582

Goldstein NB, Koster MI, Jones KL, Gao B, Hoaglin LG, Robinson SE, Wright MJ, Birlea SI, Luman A, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, Birlea SA.  Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the beta-catenin pathway in the hair follicle bulge stem cells.  J Invest Dermatol 138: 657-668, 2018.  PMID: 29054607 / PMC6135256

Hintzsche JD, Yoo M, Kim J, Amato CM, Robinson WA, Tan AC.  IMPACT web portal: Oncology database integrating molecular profiles with actionable therapeutics.  BMC Med Genomics 11: 26, 2018.  PMID: 29697364 / PMC5918430

Keysar S, Eagles J, Miller B, Jackson BC, Chowdhury FN, Reisinger J, Chimed TS, Le PN, Morton JJ, Somerset H, Varella-Garcia M, Tan AC, Song JI, Bowles DW, Reyland ME, Jimeno A.  Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene events associated with tumor progression.  Clin Cancer Res 24: 2935-2943, 2018.  PMID: 29555661 / PMC6004240

Kim J, Yoo M, Shin J, Kim H, Kang J, Tan AC.  Systems pharmacology-based approach of connecting disease genes in genome-wide association studies with traditional Chinese medicine.  Int J Genomics 2018: 7697356, 2018.  PMID: 29765977 / PMC5885494

Kim S, Park D, Choi Y, Lee K, Kim B, Jeon M, Kim J, Tan AC, Kang J.  A pilot study of biomedical text comprehension using an attention-based deep neural reader: Design and experimental analysis.  JMIR Med Inform 6: e2, 2018.  PMID: 29305341 / PMC5783222

Klauck PJ, Bagby SM, Capasso A, Bradshaw-Pierce EL, Selby HM, Spreafico A, Tentler JJ, Tan AC, Kim J, Arcaroli JJ, Purkey A, Messersmith WA, Kuida K, Eckhardt SG, Pitts TM.  Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.  BMC Cancer 18: 136, 2018.  PMID: 29402316 / PMC5800287

Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G.  High-efficiency RNA-based reprogramming of human primary fibroblasts.  Nat Commun 9: 745, 2018.  PMID: 29467427 / PMC5821705

Lee K, Kim B, Choi Y, Kim S, Shin W, Lee S, Park S, Kim S, Tan AC, Kang J.  Deep learning of mutation-gene-drug relations from the literature.  BMC Bioinformatics 19: 21, 2018.  PMID: 29368597 / PMC5784504

Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC.  ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.  Oncotarget 9: 8823-8835, 2018.  PMID: 29507657 / PMC5823650

Ross BC, Boguslav M, Weeks H, Costello JC.  Simulating heterogeneous populations using Boolean models.  BMC Syst Biol 12: 64, 2018.  PMID: 29879983 / PMC5992775

Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL.  Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation.  J Clin Invest 128: 2535-2550, 2018.  PMID: 29757193 / PMC5983346

Yue Z, Zheng Q, Neylon MT, Yoo M, Shin J, Zhao Z, Tan AC, Chen JY.  PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology.  Nucleic Acids Res 46: D668-D676, 2018.  PMID: 29126216 / PMC5753198

2017

Astling DP, Heft IE, Jones KL, Sikela JM.  High resolution measurement of DUF1220 domain copy number from whole genome sequence data.  BMC Genomics 18: 614, 2017.  PMID: 28807002 / PMC5556342

Donson AM, Apps J, Griesinger AM, Amani V, Witt DA, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Kleinschmidt-DeMasters BK, Handler MH, Tan AC, Gore, Virasami A, Gonzalez-Meljem JM, Jacques TS, Martinez-Barbera JP, Foreman NK, Hankinson, for the Advancing Treatment for Pediatric Craniopharyngioma Consortium.  Molecular analyses reveal inflammatory mediators in the solid component and cyst fluid of human adamantinomatous craniopharyngioma.  J Neuropathol Exp Neurol 76: 779-788, 2017.  PMID: 28859336 / PMC6005018

Gehring AM, Astling DP, Matsumi R, Burkhart BW, Kelman Z, Reeve JN, Jones KL, Santangelo TJ.  Genome replication in Thermococcus kodakarensis independent of Cdc6 and an origin of replication.  Front Microbiol 8: 2084, 2017.  PMID: 29163389 / PMC5663688

Griesinger AM, Witt DA, Grob ST, Georgio Westover SR, Donson AM, Sanford B, Mulcahy Levy JM, Wong R, Moreira DC, DeSisto JA, Balakrishnan I, Hoffman LM#, Handler MH, Jones KL, Vibhakar R, Venkataraman S, Foreman NK.  NF-kappaB upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.  Neuro Oncol 19: 1350-1360, 2017.  PMID: 28510691 / PMC5596179

Lummus SC, Donson AM, Gowan K, Jones KL, Vibhakar R, Foreman NK, Kleinschmidt-DeMasters BK.  p16 Loss and E2F/cell cycle deregulation in infant posterior fossa ependymoma.  Pediatr Blood Cancer 64: e26656, 2017.  PMID: 28548702 / PMC5647247

Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL.  Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia.  PLoS One 12: e0189536, 2017.  PMID: 29253007 / PMC5734749

Nelson-Taylor SK, Le AT, Yoo M, Schubert L, Mishall KM, Doak A, Varella-Garcia M, Tan AC, Doebele RC.  Resistance to RET-inhibition in RET-rearranged NSCLC is mediated by reactivation of RAS/MAPK signaling.  Mol Cancer Ther 16: 1623-1633, 2017.  PMID: 28500237 / PMC5544556

Ohm AM, Tan AC, Heasley L, Reyland ME.  Co-dependency of PKCdelta and K-Ras: Inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.  Oncogene 36: 4370-4378, 2017.  PMID: 28368426 / PMC5532068

Scott AJ, Song EK, Bagby S, Purkey A, McCarter M, Gajdos C, Quackenbush KS, Cross B, Pitts TM, Tan AC, Eckhardt SG, Fenton H, Arcaroli J, Messersmith WA.  Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.  PLoS One 12: e0187173, 2017.  PMID: 29091939 / PMC5665512

Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR.  Allele-specific DNA methylation and its Interplay with repressive histone marks at promoter-mutant TERT genes.  Cell Rep 21: 3700-3707, 2017.  PMID: 29281820 / PMC5747321

Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X.  Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.  J Biol Chem 292: 15105-15120, 2017.  PMID: 28673964 / PMC5592685

Zhou K, Spillman MA, Behbakht K, Komatsu JM, Abrahante JE, Hicks D, Schotl B, Odean E, Jones KL, Graner MW, Bemis LT.  A method for extracting and characterizing RNA from urine: For downstream PCR and RNAseq analysis.  Anal Biochem 536: 8-15, 2017.  PMID: 28803886 / PMC - In Process (NIHMS #964083)