We are a team of researchers led by Dr. Trevor Nydam where we study coagulation and how it can impair or heal organs after an injury.
Our Mission
Our mission is to train the next generation of physician-scientists and conduct high-impact research that improves the lives of organ transplant recipients!
Our research focuses on 3 main areas:
- Global Coagulation
- Ex Vivo Perfusion
- Microfluidics
We have been working on novel solutions to improve organ preservation and graft function while also investigating ways to manage deceased donors to increase availability, and improve organ function and long-term survival.
We are evaluating the mechanisms that drive fibrinolysis dysfunction in both the recipient and donor organ. At the same time, we are developing clinical expertise in advance organ recovery strategies. These include normothermic regional perfusion of the donor (extracorporeal perfusion of abdominal organs) and machine perfusion of the liver after it has been removed from the donor before implant in the donor. These research efforts will not only lead to increasing our graft survival but will also increase the number of organs utilized for transplantation.
Overall, these efforts have the potential to make a large impact on reducing the demand on organs in patients awaiting lifesaving transplants in the setting of end stage liver disease.
Featured this year:
Patient years lost due to cytomegalovirus serostatus mismatching in the scientific registry of transplant recipients by Abidi Maheen Z., Schold Jesse D., Kaplan Bruce, Weinberg Adriana, Erlandson Kristine M., Malamon John S.
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Ethical Considerations for Simultaneous vs Sequential Liver–Kidney Donation From the Same Live Donor: Donor(s) Selection Is Key by Yanik Bababekov, Elizabeth Pomfret
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Sleeve Gastrectomy Reduces the Need for Liver Transplantation in Patients with Obesity and NonâAlcoholic Steatohepatitis: a Predictive Model by Rouhi AD, Castle RE, Hoeltzel GD, Williams NN, Dumon KR, Baimas-George M, Wachs M, Nydam TL, Choudhury RA.
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Association of procurement technique with organ yield and cost following donation after circulatory death by Syed Shahyan Bakhtiyar, Tiffany E. Maksimuk, John Gutowski, Sarah Y. Park, Michael T. Cain, Jessica Y. Rove, T. Brett Reece, Joseph C. Cleveland Jr., James J. Pomposelli, Yanik J. Bababekov, Trevor L. Nydam, Jesse D. Schold, Elizabeth A. Pomfret, Jordan R.H. Hoffman.
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Successful Extension of Vascularized Composite Allograft Perfusion Cold Storage to 24 h in a Rat Hindlimb Transplant Model by Patricia K. Ng, Daniel Yoeli, Jun L. Huang, Yanyan Luo, Yong Wang, Baotong Li, Zhihong Wang, Jesse D. Schold, Shweta Jain, Annam A. Su, David W. Mathes, Kimberly M. Washington, Elinor Farkash, Anjay H. Jani, Chih-Ang Huang.
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