We are a team of researchers led by Dr. Trevor Nydam where we study coagulation and how it can impair or heal organs after an injury.
Our Mission
Our mission is to train the next generation of physician-scientists and conduct high-impact research that improves the lives of organ transplant recipients!
Our research focuses on 3 main areas:
- Global Coagulation
- Ex Vivo Perfusion
- Microfluidics
We have been working on novel solutions to improve organ preservation and graft function while also investigating ways to manage deceased donors to increase availability, and improve organ function and long-term survival.
We are evaluating the mechanisms that drive fibrinolysis dysfunction in both the recipient and donor organ. At the same time, we are developing clinical expertise in advance organ recovery strategies. These include normothermic regional perfusion of the donor (extracorporeal perfusion of abdominal organs) and machine perfusion of the liver after it has been removed from the donor before implant in the donor. These research efforts will not only lead to increasing our graft survival but will also increase the number of organs utilized for transplantation.
Overall, these efforts have the potential to make a large impact on reducing the demand on organs in patients awaiting lifesaving transplants in the setting of end stage liver disease.
Featured this year:
Contribution of Donor Hospital Characteristics to Deceased Donor Organ Recovery Rates by Lopez R, Mohan S, Vail EA, Rodrigue JR, Arrigain S, Brosi D, LaVanchy R, Nydam T, Schold JD.
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How contemporary living kidney donor transplants compare to prepandemic trends: An interrupted time series analysis by Brosi DN, Lopez R, Schold JD, et al.
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Recipient Human Leukocyte Antigen-DR Homozygosity and Access to Quality Kidneys by Deena N. Brosi, Rocio Lopez, Susana Arrigain, Ryan LaVanchy, Akansha Agrawal, Dylan Isaacson, Anat R. Tambur, Jesse D. Schold.
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Citizenship Status and Deceased Organ Donation in the USA by Katherine Rizzolo, Jesse D. Schold, Samantha M. Noreen, Alice Toll, Neil R. Powe, Lilia Cervantes.
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The Associations Between Individual- Versus Neighborhood-level Incomes and Kidney Transplant Outcomes by Mupfudze TG, Handarova D, Noreen SM, Mohan S, Schold JD, Stewart DE.
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