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Incessant Atrial Tachycardia From the Left Atrial Appendage Treated With Appendage Ligation
Pub Date: 6/24/2024Journal: JACC Case Rep. 2024 Jun 4;29(13):102375.Authors: Yonathan F Melman Eric M Lindley Abishek Kashyap Rami Alharethi Peter Smit Daniel Gutteridge Joseph Palatinus Annie OesterlingA previously healthy man presented in shock due to incessant tachycardia. He ultimately required extracorporeal membrane oxygenation for support and clipping of his appendage for arrhythmia control. This case highlights the importance of early recognition of cardiogenic shock, aggressive hemodynamic support, and a multidisciplinary approach to managing these challenging arrhythmias.
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Initial Validation of a Sacroiliac Joint-Specific Disability Questionnaire
Pub Date: 5/1/2023Journal: Orthopedics. 2023 Nov-Dec;46(6):345-351.Authors: Vikas V Patel Eric E Sawyer Paul E Mintken Lori A Michener Claire L Cofer Emily M LindleyPMID: 37126835Low back pain is a multidimensional disorder that can originate from a variety of pain generators, including the sacroiliac (SI) joint. Although the Oswestry Disability Index (ODI) is often used in SI joint treatment studies, the effects of the SI joint on functional disability are likely different from those of other low back pain generators. Thus, we developed the Denver SI Joint Questionnaire (DSIJQ) and performed validation testing in patients (n=24) with SI joint-specific pain at baseline,...
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Recombinant Human Bone Morphogenetic Protein-2 Improves Spine Fusion in a Vitamin D-Deficient Rat Model
Pub Date: 10/20/2020Journal: Int J Spine Surg. 2020 Oct;14(5):694-705.Authors: Vikas V Patel Zachary R Wuthrich Alicia Ortega Virginia L Ferguson Emily M LindleyCONCLUSIONS: Overall, vitamin D deficiency decreased trabecular bone microarchitecture, and treatment with rhBMP-2 improved outcomes across all vitamin D groups.
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Reply to Letter to Editor: Strain in Posterior Instrumentation Resulted by Different Combinations of Posterior and Anterior Devices for Long Spine Fusion Constructs
Pub Date: 5/9/2018Journal: Spine Deform. 2018 May-Jun;6(3):335-340.Authors: Christopher J Kleck Damian Illing Emily M Lindley Andriy Noshchenko Vikas V Patel Cameron Barton Todd Baldini Christopher M J Cain Evalina L BurgerPMID: 29735147No abstract
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Positioning Performance of Power and Manual Drivers in Posterior Spinal Fusion Procedures
Pub Date: 8/19/2017Journal: Appl Bionics Biomech. 2017;2017:7262841.Authors: J Micah Prendergast Alexander C Perry Vikas V Patel Emily M Lindley Mark E RentschlerThis work presents an analysis and comparison of the efficacy of two methods for pedicle screw placement during posterior spinal fusion surgery. A total of 100 screws (64 manual and 36 power driven), all placed utilizing a surgical navigation system, were analyzed and compared. Final screw placement was compared to initial surgical plans using the navigation system, and the final screw locations were analyzed on the basis of angular deviation from these planned trajectories as well as screw...
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Cervical facet force analysis after disc replacement versus fusion
Pub Date: 3/25/2017Journal: Clin Biomech (Bristol). 2017 May;44:52-58.Authors: Vikas V Patel Zachary R Wuthrich Kirk C McGilvray Matthew C Lafleur Emily M Lindley Derrick Sun Christian M PuttlitzPMID: 28340364BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion.
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Strain in Posterior Instrumentation Resulted by Different Combinations of Posterior and Anterior Devices for Long Spine Fusion Constructs
Pub Date: 1/1/2017Journal: Spine Deform. 2017 Jan;5(1):27-36.Authors: Christopher J Kleck Damian Illing Emily M Lindley Andriy Noshchenko Vikas V Patel Cameron Barton Todd Baldini Christopher M J Cain Evalina L BurgerPMID: 28038691CONCLUSIONS: Different devices modify strain in low posterior instrumentation, which is higher after transforaminal and posterior techniques, specifically with spinopelvic fixation.
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An analysis of spine fusion outcomes in sheep pre-clinical models
Pub Date: 5/12/2016Journal: Eur Spine J. 2017 Jan;26(1):228-239.Authors: Emily M Lindley Cameron Barton Thomas Blount Evalina L Burger Christopher M J Cain Howard B Seim A Simon Turner Vikas V PatelPMID: 27165183CONCLUSIONS: Recommended timeframes for future studies designed to show either superiority over controls or equivalent outcomes with controls were developed based on aggregate results. Designating ideal study endpoints for sheep fusion models has both ethical implications associated with responsible use of animals in research, and economic implications given the cost of animal research. The current results can guide the development of future research methods and help investigators choose...
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Sacroiliac Joint Pain and Its Treatment
Pub Date: 2/19/2016Journal: Clin Spine Surg. 2016 Mar;29(2):42-8.Authors: Ralph F Rashbaum Donna D Ohnmeiss Emily M Lindley Scott H Kitchel Vikas V PatelPMID: 26889985The sacroiliac joint (SIJ) as a source of symptoms has been controversial; however, as knowledge about the joint increased, its role as a pain generator in patients complaining of symptoms that are often attributed to spinal pathology has become better appreciated. The literature reports that the SIJ is the pain origin in as many as 30% of patients presenting with low back pain. Clinically, the SIJ can be challenging to evaluate; however, assessing pain location, patient posture/movement, and...
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Cardiovascular Risk Assessment and Management in Prerenal Transplantation Candidates
Pub Date: 11/11/2015Journal: Am J Cardiol. 2016 Jan 1;117(1):146-50.Authors: Eric M Lindley Amanda K Hall Jordan Hess Jo Abraham Brigham Smith Paul N Hopkins Fuad Shihab Frederick Welt Theophilus Owan James C FangPMID: 26552506Cardiovascular (CV) assessment in prerenal transplant patients varies by center. Current guidelines recommend stress testing for candidates if ≥ 3 CV risk factors exist. We evaluated the CV assessment and management in 685 patients referred for kidney transplant over a 7-year period. All patients had CV risk factors, and the most common cause of end-stage renal disease was diabetes. Thirty-three percent (n = 229) underwent coronary angiography. The sensitivity of stress testing to detect...
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Patient-Controlled Transdermal Fentanyl Versus Intravenous Morphine Pump After Spine Surgery
Pub Date: 9/17/2015Journal: Orthopedics. 2015 Sep;38(9):e819-24.Authors: Emily M Lindley Kenneth Milligan Ryan Farmer Evalina L Burger Vikas V PatelPMID: 26375541Patient-controlled analgesia (PCA) is regularly used to manage pain following major surgery. The fentanyl hydrochloride iontophoretic transdermal system (ITS) was developed to overcome some of the limitations of intravenous (IV) PCA. The small, self-adhesive, needle-free disposable system is applied to the skin on the upper arm or chest and is controlled by patients clicking a button on the device. The authors identified patients who were underwent spinal surgery from 2 prior multicenter,...
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Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis
Pub Date: 8/25/2015Journal: World J Orthop. 2015 Aug 18;6(7):537-58.Authors: Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher Mj Cain Vikas V Patel Andrew P BradfordCONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria.
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What Is the Clinical Relevance of Radiographic Nonunion After Single-Level Lumbar Interbody Arthrodesis in Degenerative Disc Disease?: A Meta-Analysis of the YODA Project Database
Pub Date: 8/15/2015Journal: Spine (Phila Pa 1976). 2016 Jan;41(1):9-17.Authors: Andriy Noshchenko Emily M Lindley Evalina L Burger Christopher M J Cain Vikas V PatelPMID: 26274529CONCLUSION: The presence of radiographic fusion is clinically significant, as patients with fusion had better clinical outcomes at 1 and 2 years postoperative than those with nonunion; however, patient-centered clinical outcomes should also be taken into consideration as independent, complimentary variables when assessing treatment success.
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Perioperative and long-term clinical outcomes for bone morphogenetic protein versus iliac crest bone graft for lumbar fusion in degenerative disk disease: systematic review with meta-analysis
Pub Date: 6/20/2014Journal: J Spinal Disord Tech. 2014 May;27(3):117-35.Authors: Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher M J Cain Vikas V PatelPMID: 24945290CONCLUSIONS: BMP, in particular rhBMP-2, is a good alternative to autogenous bone graft, especially in cases when harvesting of autologous bone is contraindicated or undesirable, operation time is limited, and there are no contraindications for BMP use.However, the current study did not reveal evidence robust enough to develop strong medical recommendations concerning BMP use for lumbar arthrodesis in degenerative disk disease.
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Long-term Treatment Effects of Lumbar Arthrodeses in Degenerative Disk Disease: A Systematic Review With Meta-Analysis
Pub Date: 6/6/2014Journal: J Spinal Disord Tech. 2015 Nov;28(9):E493-521.Authors: Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher M J Cain Vikas V PatelPMID: 24901878CONCLUSIONS: This review indicates that surgical stabilization of the lumbar spine is an effective treatment for LS; in particular, for patients with severe chronic low back pain that has been resistant to ≥3 months of conservative therapy.
Department of Orthopedics
School of Medicine
Welcome to Lindley Lab
Lab Director, Emily M. Lindley, PhD
Non-Opioid Alternatives for Chronic Musculoskeletal Pain
Cannabis and Cannabinoids Research
Welcome to Lindley Lab
Emily M. Lindley, PhD
Assistant Professor of Orthopedics
Director of the Colorado Cannabis Research Consortium (C2RC)
Our research aims to identify non-opioid alternatives for the treatment of chronic musculoskeletal pain. Chronic orthopedic pain conditions, such as back pain and knee pain, are highly prevalent and disabling conditions that are often treated with prescription opioids. The number of individuals using opioids for non-cancer chronic pain reached approximately 275 million in 2016. Unfortunately, this increase in opioid use is also associated with opioid abuse and overdose; each day, 90 Americans die from opioid overdose. Thus, there is an urgent need to find alternative treatments to reduce or eliminate opioid use for chronic pain conditions. One such alternative that has gained increased recognition in recent years is medical cannabis. Our lab is currently focused on studying the health effects of cannabis and cannabinoids for chronic musculoskeletal pain.
Projects
Cannabis and Cannabinoids
There is growing evidence that cannabis and cannabinoids (the active chemicals in the cannabis plant) are effective at treating chronic pain in adults. However, the majority of clinical trials have been conducted in patients with cancer pain, neuropathic pain (nerve pain), and mixed heterogeneous pain conditions. Despite the prevalence of musculoskeletal pain conditions, there have been no high-quality clinical trials of cannabis for these chronic pain conditions. Our lab is filling this critical gap in knowledge by conducting clinical trials of cannabis and cannabinoids for chronic orthopedic pain conditions.Publications
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Incessant Atrial Tachycardia From the Left Atrial Appendage Treated With Appendage Ligation
Pub Date: 6/24/2024Journal: JACC Case Rep. 2024 Jun 4;29(13):102375.Authors: Yonathan F Melman Eric M Lindley Abishek Kashyap Rami Alharethi Peter Smit Daniel Gutteridge Joseph Palatinus Annie OesterlingA previously healthy man presented in shock due to incessant tachycardia. He ultimately required extracorporeal membrane oxygenation for support and clipping of his appendage for arrhythmia control. This case highlights the importance of early recognition of cardiogenic shock, aggressive hemodynamic support, and a multidisciplinary approach to managing these challenging arrhythmias.
Contact Us
Contact Us
Lindley Lab
Mail Stop F432
Fitzsimmons Building
13001 E. 17th Place, Room NG006A
Aurora, CO 80045
Office: 303-724-0239
Emily.Lindley@cuanschutz.edu