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Division of Medical Oncology

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    • Division Head | Wells Messersmith, MD, FACP
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DOEBELE RESEARCH LAB

Research Focus

The overall focus of the Doebele laboratory is the study of oncogene-targeted therapy in cancer. Initially our lab focused on a particular subtype of oncogenes termed gene fusions such as ALK, ROS1, RET in lung cancer, defining how cancer cells become resistant to oncogene targeted therapies.

Knowing that patient responses to therapy and emergent drug resistance mechanisms vary by patient, and thus one cell line model for each oncogene type cannot be representative, we are also building libraries of human derived cell line models for ALK, ROS1, RET and other oncogene subtypes to better understand interpatient heterogeneity for the development of new therapies.

Robert Doebele, MD, PhD

Principal Investigator

Nan Chen, BS

Predoctoral Trainee

Logan Tyler, BS

Predoctoral Trainee

Selected Publications

McCoach CE, Le AT, McGowan K, Jones K., Schubert L, Doak A, Estrada-Bernal A, Davies KD, Merrick, DT, Bunn PA, Purcell WT, Dziadziuszko R, Varella-Garcia M, Aisner DL, Camidge DR, and Doebele RC. Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer. Clin Cancer Res. 2018 Mar 29. pii: clincanres.2588.2017. doi: 10.1158/1078-0432.CCR-17-2588. [Epub ahead of print]. PMID: 29599410. 

Drilon A, Ou SI, Cho BC, Kim DW, Lee J, Lin JJ, Zhu VW, Ahn MJ, Camidge DR, Nguyen J, Zhai D, Deng W, Huang Z, Rogers E, Liu J, Whitten J, Lim JK, Stopatschinskaja S, Hyman DM, Doebele RC, Cui JJ, Shaw AT. Repotrectinib (TPX-0005) is a next generation ROS1/TRK/ALK inhibitor that potently inhibits ROS1/TRK/ALK solvent front mutations.  Cancer Discov. 2018 Aug 9. pii: CD-18-0484. doi: 10.1158/2159-8290.CD-18-0484. [Epub ahead of print]. PMID: 30093503. 

Hong DS, Bauer TM, Lee JJ, Dowlati A, Brose MS, Farago AF, Taylor M, Shaw AT, Montez S, Meric-Bernstam F, Smith S, Tuch BB, Ebata K, Cruickshank S, Cox MC, Burris HA 3rd, Doebele RC. Larotrectinib in adult patients with solid tumours: a multicentre, open-label, phase I dose-escalation study.  Ann Oncol. 2019 Jan 8. doi: 10.1093/annonc/mdy539. [Epub ahead of print] PMID: 30624546​

Full List of Publications

Medical Oncology (SOM)

CU Anschutz

Research I South

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Aurora, CO 80045


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