Dr. Patricia C. Heyn has been involved in health promotion and disease prevention research for over 20 years. Her investigations related to (1) health outcomes and aging; (2) preventing or delaying the onset of Alzheimer’s disease with exercise and/or cognitive training; (3) evaluating protective/risk factors associated with cardiovascular disease and cognitive decline; (4) early detection of frailty including mobility impairments; and (5) evaluating emerging technologies for individuals with cognitive impairments has been funded by the National Institutes of Health, U.S. Department of Health and Human Services Administration for Community Living, Coleman Institute, and the J.T. Tai Foundation
Dr. Baer is co-investigator and the primary study physician for this proposal. She is a physiatrist who specializes in adult neurorehabilitation with a particular focus upon adults with CP. She will assist with the clinical needs of the study participants and will help determine the appropriate course of action if abnormal test results arise. Dr. Baer had decades of experience treating individuals with CP. Having served as the primary physician since the inception of the original CPAT grant, she understands the study design. Dr. Baer will also assist with the recruitment of the participants by identifying potential participants from her adult clinics. She will participate in all research meetings and will assist with the preparation of publications.
Dr. Boyd received a PhD in Medical Sciences and a master’s in biotechnology at the University of South Florida, and his research focused on the immunology and the cellular mechanisms of neurodegenerative diseases. He has been collaborating with the CPAT research team since the inception of the original grant. He is faculty and has his lab at the Rocky Mountain Alzheimer’s Disease Center. He is also a faculty in the Department of Neurology at the University of Colorado Denver, School of Medicine. He works under the leadership of Dr. Huntington Potter, the Director of the Alzheimer's Disease Research and Clinical Center, and the Director of the Alzheimer’s Disease Program within the Linda Crnic Institute for Down Syndrome. He together with Dr. Potter will provide expertise and lead the inflammatory blood analysis and immunoassays of this study. Growth factors assays, and inflammatory biomarkers will be analyzed by Dr. Boyd at the Rocky Mountain Alzheimer’s Disease Center laboratory. He will participate in all meetings of the research team and assist the PI with the preparation of publications.
Dr. Coughlan is Senior Faculty Research Instructor in the Department of Neurology and a member of the University of Colorado Alzheimer’s and Cognition Center (CUACC) and the Linda Crnic Institute for Down Syndrome. Her research and teaching experience have been extensive, resulting in publications focused on topics that pertain directly to understanding the molecular mechanisms underlying Alzheimer’s disease in both the typical population and in people with Down syndrome. Dr. Coughlan has collaborated with the CPAT team to examine all aspects of the blood biomarkers identified, including data quality, with the goal of understanding the pathobiological mechanisms underlying the conditions that affect individuals with CP throughout their life.
Dr. Davis is a pediatric physiatrist and assistant professor at the University of California San Francisco. He cares for young people with amputations or limb deficiencies, and for those who have issues with physical function resulting from brain or spinal cord injuries, rheumatic disorders, cancer, neurological conditions or musculoskeletal conditions. Dr. Davis earned his medical degree at St. Louis University School of Medicine. He completed a combined residency in pediatrics and physical medicine and rehabilitation at the University of Colorado School of Medicine. Dr. Davis was mentored by the CPAT research team and has developed an increasing interest and focus on the diagnosis of cerebral palsy.
Dr. De is a co-investigator and the study orthopedic surgeon for this proposal. Dr. De is a core faculty member of CGMA, and has specialized training in pediatric orthopedics, neuromuscular disorders, gait analysis, limb deformity, and pediatric and adolescent fracture care. He graduated with honors from Emory University School of Medicine in 2006. He has more than 13 years of diverse experiences, especially in cerebral palsy, amputees, sports medicine, general orthopedics, and pediatric medicine. Dr. De is affiliated with the Children’s Hospital Colorado, and he is currently an assistant professor in orthopedics at UC Denver. He understands well the needs of people with cerebral palsy. His extensive experience in both private practice and academic medicine related to neuromuscular disorders, gait analysis, and limb deformity make him an ideal co-investigator for this study. Dr De will assist with the 1) serious adverse events (SAE) and unanticipated problems 2) participants’ safety and wellbeing during study procedures, 3) will review medical history, medications, instrumented gait and physical exams 4) communicates by the CCTSI safety committee and IRB as needed. He will refer participants to their primary care physician when abnormal test findings are identified. He will participate in all meetings of the research team, assist the PIs with the preparation of annual renewals & progress reports, and assist with the publication of the study findings.
Dr. MacCarthy was diagnosed with Cerebral Palsy as an infant and knows firsthand the challenges and unique facets of growing up, transitioning to adulthood, and aging with a
disability. He has interacted with people with a wide variety of disabilities in a range of recreational and clinical settings which ultimately led to a deep fascination with the field of Physical Medicine and Rehabilitation. He completed his fellowship in Pediatric Rehabilitation Medicine at the Children’s Hospital of Pittsburgh, and in addition to career-long clinical care of individuals with CP, he is committed to studying the conditions and hardships that individuals with CP face on a daily basis. He is interested in transitional care, helping to improve self-advocacy for teenagers and young adults with childhood disabilities. He is currently at the Prisma Health Children's Hospital - Midlands
Nancy is a board-certified pediatric physical therapist with over 10 years of experience in neurodevelopmental pediatrics. Nancy works in the Center for Gait and Movement Analysis at Children’s Colorado as a collaborative multi-disciplinary team member to perform gait analysis and develop recommendations to optimize gait and overall function for children with complex gait disorders. Nancy has specific expertise in idiopathic toe walking (ITW) and has lectured on this topic in pediatric physical therapy programs and at national physical therapy meetings. She is a member of the American Physical Therapy Association ITW Clinical Practice Guideline Development Group to develop evidence-based physical therapy practice evaluation and treatment guidelines. Nancy is a doctoral candidate in the Doctor of Health Science program in Drexel University’s College of Nursing and Health Professions where her dissertation research uses qualitative methods to explore the nature of decision making for adult patients considering hip preservation surgery.
Dr. Ng is a translational gerontologist and neuroscientist, specialized in geriatric neurological and psychiatric conditions. Recognizing that there is an unmet need in translating research findings into the community and clinics, he utilizes translational and trans-disciplinary approaches in his investigations, integrating wet laboratory techniques, psychosocial scales, randomized controlled trials (RCTs), and epidemiological methods. Apart from being the active co-investigator for grants in both Singapore and the U.S., he has recently initiated and is currently leading several collaborative projects, based in five countries, validating the use of salivary biomarkers in Alzheimer’s Disease. As part of the CPAT research team, he has help identify similarities between individuals with Alzheimer’s Disease and Cerebral Palsy.
Dr. Reistetter is an experienced disability and rehabilitation researchers. He is an Associate Dean of Research and Professor Occupational Therapy at the UT Health San Antonio. He is the PI of a project evaluating patient-centered outcomes research among older adults with stroke. He has been part of the CPAT Science Team since 2014 and he served as an advisory board member and consultant on the original CPAT study. In this capacity, he draws upon his clinical, research and personal experience to support the innovative and significant efforts of the CPAT project. As an individual with cerebral palsy, his personal experience coupled with his clinical, and research expertise makes him well qualified to serve as an evaluator, investigator and advisory board member in this study. He will participate in all meetings of the research team by teleconference and perform three annual on-site visits (1/year) during the study period to participate in the evaluation and advisory committee.
Is a Research Assistant in the CGMA who supports Dr. Carollo and Dr. Rhodes. Alex began at CGMA in May 2016 after graduating from University of Colorado, Denver with a degree in Biology and a minor in Chemistry. Alex is an integral part of the Neuromuscular Disorders and Cerebral Palsy Program, CGMA, and Sports Medicine Program. In his spare time, he plays soccer and runs.
Dr. Pan is a Co-Investigator and the Study Senior Biostatistician. He has been instrumental in the CPAT publications and presentations (see appendix for the full CPAT study references). Dr. Pan is an associate professor in the Department of Pediatrics and a member of the Children’s Hospital Colorado Research Institute biostatistical core. Dr. Pan has expertise in a wide array of statistical methods beyond basic design and analysis. This includes having worked with complex methods in disability and rehabilitation research, such as methods in categorical and multivariate statistics. He has also provided statistical support on multiple projects at the CGMA including the original CPAT study. He has unique expertise in developing analytical methods for reducing and consolidating high dimensional gait data to composite indices of performance. He will have overall responsibility for the statistical plan and report. He will participate in all research meetings and assist with the preparation of annual renewals, progress reports, and publications.