Dara Aisner MD, PhD

Publications and Presentations

  Journal Publications:

• D O'Mahony, I Debnath, J Janik, DL Aisner, E Jaffe, T Waldmann, J Morris: Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience. Leuk Lymphoma 2008, 49:439-46.
• DL Aisner, DM Berman, A Maker, S Rosenberg: Loss of S100 antigenicity in malignant melanoma. Hum Pathol 2005, 36:1016– 1019.
• DL Aisner, WE Wright, JW Shay: Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev 2002, 12:80-5.
• X Yi, DM White, DL Aisner, JA Baur, WE Wright, JW Shay: An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2000, 2:433-40.
• PA McChesney, DL Aisner, BC Frank, WE Wright, JW Shay: Telomere dynamics in cells with introduced telomerase: a rapid assay for telomerase activity on telomeres. Mol Cell Biol Res Commun 2000, 3:312-8.
• VM Tesmer, LP Ford, SE Holt, BC Frank, X Yi, DL Aisner, M Ouellette, JW Shay, WE Wright: Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol Cell Biol 1999, 19:6207-16.
• MM Ouellette, DL Aisner, I Savre-Train, WE Wright, JW Shay: Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun 1999, 254:795-803.
• SE Holt, DL Aisner, J Baur, VM Tesmer, M Dy, M Ouellette, JB Trager, GB Morin, DO Toft, JW Shay, et al: Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 1999, 13:817-26.

• SE Holt, DL Aisner, JW Shay, WE Wright: Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci U S A 1997, 94:10687-92.

   Books and Book Chapters:

• AR Sepulveda and DL Aisner: Molecular Basis of Diseases of the Gastrointestinal Tract. In "Molecular Pathology: The Molecular Basis of Human Disease" by Coleman WB and Tsongalis GJ; Academic Press, Burlington, MA, 2009 pp365-394.
• Roundtable on Evidence Based Medicine: The Learning Healthcare System Workshop Summary ed. L Olsen, DL Aisner,  JM McGinnis; National Academies Press, Washington, D.C., 2007 

  Abstracts/Presentations:

• DL Aisner, Y Yao, Y Wen, AR Sepulveda: Increasing CpG methylation in a four gene panel during progression of ulcerative colitis to dysplasia, poster presentation at Association for Molecular Pathology Annual Meeting, November 2009, Orlando, Florida
• D Nielsen, J Strubinger, C McGrath, CD Watt, DL Aisner, VM Van Deerlin: Clinical performance of Invader v2 ASR assay and correlation with HPV genotyping, poster presentation at Assocation for Molecular Pathology Annual Meeting, November 2009, Orlando, Florida
• DL Aisner, Y Yao, Y Wen, AR Sepulveda: Progressive increase of MGMT (O6-methylguanine DNA methyltransferease) CpG methylation levels from colitis to low-grade dysplasia in ulcerative colitis, poster presentation at Digestive Diseases Week 2009, Chicago, Illinois
• DL Aisner, DM Berman, A Maker, S Rosenberg: Loss of S100 antigenicity in malignant melanoma, platform presentation at USCAP 2005, San Antonio, Texas
• DL Aisner, PA McChesney, CT Iucu, JA Baur, WE Wright, JW Shay: Characterization of putative phosphorylation sites and variants of the catalytic protein component of telomerase, Telomeres and Telomerase Symposium, Cold Spring Harbor, January, 2001.
• HD Love, S Soltaninasaab, J McAfee, DL Aisner, W LeStourgeon: hnRNP C proteins exist as a 390KDa dodecamer which binds 690nts of RNA during hnRNP assembly RNA Processing Cold Spring Harbor, January, 1995.