kabos research lab

The Kabos translational lab studies endocrine resistance, breast cancer genomics, and the role of tumor microenvironment in disease progression.  Through its development of the University of Colorado AMC patient-derived breast tumor xenograft (PDX) bank the Kabos lab has formed a rare collection of PDX tumors and cell lines of all breast cancer subtypes to form the basis of metastasis, tumor microenvironment, and obesity research.

lab personnel

selected publications

Bardia A, Kaklamani V, Wilks S, Weise A, Richards D, Harb W, Osborne C, Wesolowski R, Karuturi M, Conkling P, Bagley RG,Wang Y, Conlan MG, Kabos P. A phase 1 study of elacestrant (RAD1901), a novel selective estrogen receptor degrader, in ER-positive, HER2-negative advanced breast cancer. Journal of Clinical Oncology 2021 (Jan 29:JCO2002272. doi: 10.1200/JCO.20.02272. Online ahead of print. PMID: 33513026

Stoen E, Kagihara J, Shagisultanova E, Fisher CM, Nicklawsky A, Kabos P, Borges VF, Diamond JR.Real-world evidence from a University Hospital system regarding the uptake of adjuvant pertuzumab and/or neratinib before and after their FDA approval. Breast Cancer Res Treat. 2021 Feb 24. doi: 10.1007/s10549-021-06132-8. Online ahead of print. PMID: 33625615

Schreiber AR, Kagihara JA, Weiss JA, Nicklawsky A, Gao D, Borges VF, Kabos P, Diamond JR. Clinical Outcomes for patients with metastatic breast cancer treated with immunotherapy agents in phase I clinical trials. Front Oncol. 2021 Mar 17. PMID: 33816286

Smyth LM, Batist G, Meric-Bernstam F, Kabos P, Spanggaard I, Lluch A, Jhaveri K, Varga A, Wong A, Schram AM, Ambrose H, Carr TH, de Bruin EC, Salinas-Souza C, Foxley A, Hauser J, Lindemann JPO, Maudsley R, McEwen R, Moschetta M, Nikolaou M, Schiavon G, Razavi P, Banerji U, Baselga J, Hyman DM, Chandarlapaty S. Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer. NPJ Breast Cancer. 2021 April 16; 7(1):44. PMID: 33863913

Rao S, Han AL, Zukowski A, Kopin E, Sartorius CA, Peter Kabos, Srinivas Ramachandran. Mapping transcription factor-nucleosome dynamics from plasma cfDNA. BioRxiv. 2021 April 15 (https://doi.org/10.1101/2021.04.14.439883) Co-senior author.

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