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Johannes Menzel, Ph.D.
Postdoctoral fellow, Department of Biochemistry and Molecular Genetics
Hometown: | Whitehorse, Yukon Territory, Canada |
Education: | University of Victoria Bachelor of Science Biochemistry
University of Saskatchewan Master of Science, Anatomy and Cell Biology
University of Colorado Anschutz Medical School Ph.D. Molecular Biology |
Research: | I am interested in adaptive oncogenesis, particularly in factors associated with aging that influence initiation, progression, and relapse of cancer. I plan to leverage mouse models to investigate how age and chemotherapy-induced alterations within the bone marrow microenvironment impinge on the evolution of therapeutic resistance and self-renewal of leukemic stem cells. Currently, I am investigating how the loss or reduction of C/EBP (CCAAT-enhancer-binding proteins), a family of proteins associated with normal and malignant hematopoietic myeloid differentiation that often have reduced expression at relapse, increased self-renewal of leukemic stem cells under therapy-induced selective pressure. My hope is that a better understanding of clonal evolution will lead to therapies that prevent selection for phenotypes that mediate disease progression and drug resistance. |
| Contact: | johannes.menzel@cuanschutz.edu |
| Publications: | Link to Johannes's publications |
