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You can participate in one of the largest and most comprehensive studies of Down syndrome in the world at the 2025 National Down Syndrome Congress Annual Convention.

The Human Trisome Project (HTP) aims to significantly increase the speed of Down syndrome research and the understanding of its co-occurring conditions from congenital heart defects to cognitive dysfunction.

If you are a person with Down syndrome between six months and 89 years old, you can participate. Already participated? We'd love to see you again!

Participant getting his tongue swabbed for the HTP

Participant getting her blood drawn for the HTP

Designed to be the largest and most comprehensive study of its kind, the HTP will help us understand why individuals with Down syndrome (caused by trisomy of chromosome 21) are protected from some medical conditions, such as cancer, while highly predisposed to others, such as Alzheimer's disease and autoimmune disorders.

Sign up early to get an HTP appointment that works for you!

2026 Dates Coming Soon...

Learn More About Participating in the HTP

Our mission is ambitious, yet simple: to significantly improve the lives of people with Down syndrome by understanding how trisomy 21 causes a different disease spectrum.

This project will significantly advance our understanding of several major medical conditions and human biology in general, enabling the development of novel diagnostic and therapeutic tools to serve not only individuals with Down syndrome, but also the billions worldwide who experience conditions affected by trisomy 21.

Check out a few of our groundbreaking discoveries from HTP data.

Did you know that up to 80% of people with Down syndrome can have hearing loss during their life?

You can participate in the HTP and receive a FREE hearing test at the NDSC Annual Convention! The Crnic Institute and Boys Town National Research Hospital are teaming up to learn more about hearing and balance in Down syndrome. Learn more below.

Seleccione el botón para ver esta página en español.

You can participate in one of the largest and most comprehensive studies of Down syndrome in the world at the 2025 National Down Syndrome Congress Annual Convention.

The Human Trisome Project (HTP) aims to significantly increase the speed of Down syndrome research and the understanding of its co-occurring conditions from congenital heart defects to cognitive dysfunction.

If you are a person with Down syndrome between six months and 89 years old, you can participate. Already participated? We'd love to see you again!

Sign up early to get an HTP appointment that works for you!

2026 Dates Coming Soon...

Learn More About Participating in the HTP

Did you know that up to 80% of people with Down syndrome can have hearing loss during their life?

You can participate in the HTP and receive a FREE hearing test at the NDSC Annual Convention! The Crnic Institute and Boys Town National Research Hospital are teaming up to learn more about hearing and balance in Down syndrome. Learn more below.

Questions? You can also email us at [email protected].

COMIRB#: 15-2170 PI: Joaquin Espinosa

Seleccione el botón para ver esta página en español.

You can participate in one of the largest and most comprehensive studies of Down syndrome in the world at the 2025 National Down Syndrome Congress Annual Convention.

The Human Trisome Project (HTP) aims to significantly increase the speed of Down syndrome research and the understanding of its co-occurring conditions from congenital heart defects to cognitive dysfunction.

If you are a person with Down syndrome between six months and 89 years old, you can participate. Already participated? We'd love to see you again!

Sign up early to get an HTP appointment that works for you!

2026 Dates Coming Soon...

Learn More About Participating in the HTP

Why participate?

Who can participate?

What is involved?

What are the findings?

Did you know that up to 80% of people with Down syndrome can have hearing loss during their life?

You can participate in the HTP and receive a FREE hearing test at the NDSC Annual Convention! The Crnic Institute and Boys Town National Research Hospital are teaming up to learn more about hearing and balance in Down syndrome. Learn more below.

Questions? You can also email us at [email protected].

COMIRB#: 15-2170 PI: Joaquin Espinosa