I have devoted my professional life to understanding what makes cells become cancerous and how to turn that knowledge into the best possible treatments. I seek to empower my patients with knowledge about their disease and its treatments. For me, it is a privilege to provide cancer care and I strive to help patients realize their best possible quality of life.
Lorraine’s research is focused on studying mechanisms of drug resistance in myeloma, particularly acquired resistance to immunomodulatory drugs (IMiDs). She has established an intracellular protein flow cytometry-based platform to measure the downstream effects of IMiDs in multiple myeloma patient samples to classify how resistance occurs. Lorraine graduated from Seattle University in Cell and Molecular Biology with a minor in Chemistry. Her undergraduate research projects involved the structural/functional characterization of DNA recognition and cleavage specificity in homing endonucleases and developing a next-generation sequencing platform to study how human land use impacts urban carnivores. She also worked as an intern at Seattle Genetics in quantitative pharmacology of antibody-drug conjugates. After graduation, Lorraine joined the Cancer Biology PhD program at CU. Outside the lab, she enjoys painting and drawing, outdoor water activities, and spending time with friends and family.
Olivia Perez de Acha Lopez comes to us from Madrid, Spain. She recently received her MD from Universidad Autonoma de Madrid. Her past research was done at the Hospital Puerta de Hierro studying TKI drug resistance in liquid biopsies from patients with EGFR+ lung adenocarcinoma. Before joining us at CU, Olivia also spent last summer at the NIH studying exosomes as potential biomarkers in Alzheimer's Disease. In our group, she is evaluating immunotherapy targets, with a particular focus on the daratumumab-refractory setting. Her goal is to ultimately become a Hematologist/Oncologist, and is interviewing for the 2021 residency match in the U.S. In her free time, Olivia is a prolific traveler, having volunteered in underserved communities in diverse locations including Cuba, New Zealand, Indonesia and Cambodia. She is also a "crazy skier”, and has the goal to visit all ski resorts in North America.
Lauren recently graduated from the University of Nebraska-Lincoln in Biological Sciences with minors in Biochemistry and Piano Performance. Her project in our lab is to develop blood-based assays to measure drug sensitivity. Her undergraduate research at UNL focused on how diet affects the immune system using Drosophila melanogaster. Lauren was also an intern at Nebraska Medical Center where she studied the effects of an autophagy inhibitor on chemotherapy resistance in colon cancer. In her free time, Lauren loves making kombucha and other ferments, hiking, and playing flute in musical ensembles.
Zach’s current research is on the development of a new therapeutic drug class for multiple myeloma patients. Zach is also our lab manager and his technical expertise spans the variety of techniques we use, including multiparameter flow cytometry and in vivo models of myeloma. Prior to coming to the University of Colorado, Zach worked at Northwestern University’s Center for Innovation in Global Health Technologies in Chicago, where he helped develop molecular point-of-care diagnostics for HIV and TB. He received a master’s degree in biology from Northern Arizona University in Flagstaff, for which he focused on the characterization of bacterial and fungal soil communities. In his free time, Zach loves to explore Colorado’s numerous outdoor activities including cycling and mountain biking, as well as spending time with family.