Wednesday and Thursday, May 25th & 26th, 2022
Virtual, Gather Town
To convene researchers active in alphaherpesvirus latency to discuss current advances in a relaxed venue.
Herpes simplex virus types 1 and 2 and varicella zoster virus are neurotropic alphaherpesviruses, characterized by their ability to establish latency in cranial nerve, dorsal root, enteric, and autonomic ganglia along the entire neuraxis. While the viruses contain 70 to 86 open reading frames, most of which are expressed during productive infection, during latency, large parts of the virus genome are silenced, and virus replication is blocked. Disease associated with reactivation of latent virus is often more serious than primary infection. Understanding the molecular mechanisms of latency (establishment, maintenance, and reactivation) will set the groundwork required to develop effective therapies. To this end, the Colorado Alphaherpesvirus Latency Society has been formed with the explicit goal of providing a forum to present, discuss, and propose current and future work to understand the neurobiology of these unique human pathogens.
For further information, contact Andrew Bubak at Andrew.Bubak@cuanschutz.edu