Abbott Lab Personnel

Jordan Abbott, MD

Associate Professor, Department of Pediatrics

My training is as a clinical immunologist, which allows me to take genetic variation found in patients into the lab to determine their meaning. This approach has led to the identification of novel genetic pathways to human immune disease. We use these insights to develop new ways to improve the way we diagnose and treat human immune diseases.

Clinical Interests:
My clinical interests include immune deficiency and immune dysregulation disorders.

Education:
Medical School: MD, Weill Cornell Medical College (2006)
Graduate School: MA, Columbia University (2001)
Undergraduate School: BA, University of California–Berkeley (CA) (1997)
Residency: Children's Hospital Los Angeles Program, Pediatrics (2009)
Fellowships: National Jewish Medical and Research Center, Allergy and Immunology (2013)

List of Publications:
https://orcid.org/0000-0001-6334-5266

Brian Tooker, PhD

Postdoctoral Fellow

Dr. Brian Tooker is a post-doctoral research scientist currently working under the guidance of Dr. Jordan Abbott at the University of Colorado - Anschutz Medical Campus. Dr. Tooker received his BS in Microbiology and MS in Animal Science, both from Michigan State University, where he utilized molecular biology tools and genomics to answer questions about the host immune response to facultative intracellular bacteria.

Dr. Tooker went on to manage and set up laboratories at Iowa State University and the University of Colorado, where he built upon his pervious big data training in genomics to gain a greater understanding of T cell responses to metals using proteomic tools.

Recently, Dr. Tooker completed his PhD in Toxicology at the University of Colorado - Anschutz Medical Campus under Dr. Nichole Reisdorph. There he investigated monocyte and monocyte derived macrophage responses to polycyclic aromatic hydrocarbons mixture exposures using both classical molecular biology tools as well as untargeted metabolomics. Dr. Tooker next investigated how P. aeruginosa cytokine P450 metabolism may be leading to both bacterial growth before joining Dr. Abbott’s laboratory and investigating how mutations in the autoimmune regulator (AIRE) result in alterations in T cell maturation.

Selected Recent Publications:

1. Brian C. Tooker, Kevin Quinn, Michael Armstrong and Nichole Reisdorph. Comparing the Effects of an Exposure to a Polycyclic Aromatic Hydrocarbon (PAH) Mixture Versus Individual PAHs During Monocyte to Macrophage Differentiation: Mixture Exposure Results in Altered Immune Metrics. Journal of Applied Toxicology 2021 Feb 8. doi:10.1002/jat.4147.
   
2. Nichole Reisdorph, Audrey Hendricks, Minghua Tang, Katrina Doenges, Richard Reisdorph, Brian Tooker, Kevin Quinn, Sarah Borengasser, Yasmeen Nkrumah-Elie, Daniel Frank, Wayne Campbell and Nancy Krebs. Nutrimetabolomics reveals food-specific compounds in urine of adults consuming a DASH-style diet. Sci Rep. 2020 Jan 24;10(1):1157.
3. Brian C. Tooker, Katherine Ozawa and Lee S. Newman.  CpG Promoter Methylation Status is not a Prognostic Indicator of Gene Expression in Beryllium Challenge. Journal of Immunotoxicology. 2015 Dec 16:1-11.
4. BC Tooker, SM Brindley, ML Chiarapa-Zucca, KW Turteltaub and LS Newman. Accelerator Mass Spectrometry Detection of Beryllium Ions in the Antigen Processing and Presentation Pathway. Journal of Immunotoxicology. 2014. Jun 16:1-7.
5. BC Tooker, RP Bowler, JM Orcutt, LA Maier, HM Christensen and LS Newman. SELDI-TOF Derived Serum Biomarkers Failed to Differentiate Between Patients with Beryllium Sensitization from Chronic Beryllium Disease. Occup Environ Med. 2011 Oct; 65(10): 759-64. 
6. BC Tooker and PM Coussens.  Phagocytosis of M. paratuberculosis fails to Activate Expression of NADH Dehydrogenase and Nucleolin-Related Protein in Bovine Macrophages. 2004. Immunology Letters.  93(2-3) p. 137-42.
7. BC Tooker and PM Coussens.  Survival of M. paratuberculosis in Bovine Macrophage cells. 2002.  Veterinary Immunology and Immunopathology.  87(3-4) p. 429-437.

Angelica Ehler

Research Services Program Manager

I am currently the Research Services Program Manager for the Abbott Lab. I received my BS in Biology from the University of Colorado Denver. I have over 13 years of experience working in a research lab. 

I ventured out into the clinical world for a few years where I was responsible for HLA typing, PRA monitoring and Flow Cytometric testing that ensured donor and recipient compatibility. After working in several labs at the University of Colorado-Denver, I have grown to enjoy working in the Immunology Department. 

Publications:

Jordan, Abbott MD, MA, Angelica C Ehler, BS, Divya Jayaraman MD, Paul R. Reynolds PhD, Kanao Otsu MD, MPH, Laurie Manka MD, Erwin W. Gelfand MD.  Heterozygous IKKB activation loop mutation results in a complex immunodeficiency syndrome.  Journal of Allergy and Clinical Immunology 2020-06-15: DOI 10.1016/j.jaci.2020.06.007 

Brent E Palmer, C Preston Neff, Jonathan Lecureux, Angelica Ehler, Michelle Dsouza, Leila Remling-Mulder, Alan J Korman, Andrew P Fontenot, Ramesh Akkina.  In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice.  Journal of Immunology 2014 Jan DOI: 10.4049/jimmunol.1201108