Ongoing Projects

Burn Surgery

  1. Puradigm Infection Study
  2. Randomized Trial of Enteral Glutamine to Minimize Thermal Injury — the RE-ENERGIZE Study
  3. Epicel, Cultured Epidermal Autografts (CEA) HDE# 9900002
  4. Burn Trauma and Infection: Mechanisms By Which Inhalation Injury Exacerbates Burn Injury-Induced Pulmonary Pathology
  5. Validation of LBNP Model of Central Volume Loss in Burn Patients
  6. Comparative Evaluation of “Conventional” and Physiochemical Assessments of Acid-Base Metabolism in Burn and Trauma Patients
  7. Analyzing the Effectiveness of Nursing Driven Resuscitation Protocols in Severe Burn Injury
  8. Ambulation in the Adult Burn Population: Perception versus Actuality
  9. Alteplase in the Treatment of Acute Frostbite Injury: Institution of Protocol and Outcomes
  10. Analyzing the Ramifications of Drugs of Abuse (alcohol, marijuana, tobacco, opiates, and methamphetamines) on the Subsequent Care of Burn and Frostbite Patients
  11. A Phase III Open-Label, Controlled, Randomized, Multicenter Study Evaluating the Efficacy and Safety of Stratagraft® Skin Tissue in Promoting Autologous Skin Tissue Regeneration of Complex Skin Defects Due to Thermal Burns that Contain Intact Dermal Elements and for which Excision and Autografts are Clinically Indicated
  12. Risk Factor Analysis for the Development of Transaminitis in Oxandrolone Treated Adult Burn Patients
  13. Dronabinol for Acute Pain Management in Burn Patients that Test Positive For or Admit to Using Marijuana
  14. Evaluation of the use of Tissue Plasminogen Activator in the Treatment of Frostbite Injury
  15. The Use of Dexmedetomidine in Reducing Opioid and/or Benzodiazepine Use for Wound Care in Burn Intensive Care Unit Patients
  16. Retrospective Analysis for Sex Dimorphisms in Coagulopathy in Burn Patients
  17. Risk Factors Surrounding PTSD in Burn Patients
  18. Impact of a Mobile Phone App on Triage and Transfer to a Large Regional Burn Center
  19. Injury Patterns in Combined Trauma and Burn Patients
  20. IV Lidocaine Infusions for Treatment of Pain in Burn Patients
  21. Prevalence of Multidrug Resistant Organisms (MDRO) on Admission in Burn Patients
  22. The effects of Peri-Operative Fasting on Burn Patients
  23. A Multicenter, Multinational, Randomized, Controlled, Assessor Blinded Study, Performed in Subjects with Thermal Burns, to Evaluate the Efficacy and Safety of NexoBrid Compared to Gel Vehicle, and Compared to Standard of Care.

GI, Trauma, and Endocrine Surgery

  1. A Phase III, randomized, double-blind, multicenter study to assess the efficacy and safety of OCTAPLEX, a four-factor prothrombin complex concentrate (4F-PCC), compared to the 4F-PCC Beriplex® P/N (Kcentra), for the reversal of vitamin K antagonist induced anticoagulation in patients needing urgent surgery with significant bleeding risk. Principal Investigator: Robert McIntyre, Jr., MD.
  2. Ato-bio- Phase III, Randomized Double Blinded, Placebo-Controlled, Parallel-Group, Study of AB103 as Compared to Placebo in Patients with Necrotizing Soft Tissue Infections (NTSI). Principal Investigator: Robert McIntyre, Jr., MD.

Surgical Oncology

  1. Outcomes in Surgical Oncology. Principal Investigator: Ana Gleisner, MD.
  2. Quality of Life Following Major Laparoscopic or Open Pancreatic Resection. Principal Investigator: Ana Gleisner, MD.

Transplant Surgery

  1. Randomized Controlled Trial to Evaluate the Effect of Lost Wage Reimbursement to Potential Kidney Donors on Living Donation Rates (Donor Lost Wages Study). Multicenter Study. Local PI: Trevor Nydam, MD. Sponsors: Laura and John Arnold Foundation, American Society of Transplant Surgeons (ASTS), and Arbor Research Collaborative for Health.
  2. Identifying Fibrinolysis Sensitivity in Liver Transplant to Improve Perioperative Transfusion. Investigator Initiated. PI: Trevor Nydam, MD.
  3. Pregnancy Outcomes After Living Liver Donation: An Exploratory Retrospective Cohort Analysis. Multicenter Study. Coordinating Center: University of Pennsylvania. Local PI: Whitney Jackson, MD.

Vascular Surgery

  1. An international, multicenter, randomized, double-blind, placebo-controlled phase 3 trial investigating the efficacy and safety of rivaroxaban to reduce the risk of major thrombotic vascular events in patients with symptomatic peripheral artery disease undergoing lower extremity revascularization procedures (Voyager). Principal Investigator: Mark Nehler, MD.
  2. Zenith® Fenestrated AAA Endovascular Graft Post-Approval Study.
  3. Global Registry for Endovascular Aortic Treatment (GREAT) Outcomes Evaluation.
  4. Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI Trial). Principal Investigator: Kevin Rogers, MD.