Laboratory for Fetal and Regenerative Biology


Research Objective

The LFRB research is focused primarily in the field of healing, the response to injury, and regenerative medicine, with an emphasis on elucidating the mechanisms involved in the regenerative response to injury in the fetus, the role of stem cells in tissue repair, and the correction of abnormal healing in the adult.

The LFRB team is developing novel treatment paradigms using stem cells, gene therapy strategies, and small molecule therapeutics to promote healing and tissue regeneration in multiple tissues by modulating the inflammatory response, angiogenesis, the composition of the extracellular matrix, and progenitor cell content. The goal of this regenerative medicine approach is to restore normal tissue architecture and function and to prevent the complications of impaired healing or scar formation after injury.

Projects

  1. CNP-miR146a, a novel treatment that corrects impaired diabetic wound healing
  2. CNP-miR146a rescues lung function following Acute Lung Injury (ALI) and stops the development of Acute Respiratory Distress Syndrome (ARDS)
  3. CNP-miR146a for the treatment of ulcerative colitis (UC)
  4. Nanosilk improves the strength of diabetic skin
  5. SCF Increases in Utero-Labeled Stem Cells Migration and Improves Wound Healing
  6. Mesenchymal stem cells correct of the impaired biomechanical properties of diabetic skin by modulating microRNA‚Äź29a
  7. Mammalian Fetal Cardiac Regeneration After Myocardial Infarction
  8. Knockdown of LncRNA GAS5 enhances diabetic wound healing