University of Colorado Anschutz Medical Campus

Current Projects in the Advanced Imaging Lab

Our lab specializes in the hemodynamics of congenital heart disease as measured by 4D flow MRI. Here are some of our ongoing projects

	Image, Data Gathering and Analysis Protocols COMIRB Protocol 19-0518 \| Evaluation and Demonstration of Investigational MRI Software and Hardware COMIRB Protocol 19-1420 \| Evaluation of flow velocity, blood flow characteristics, and tissue characteristics of the cardiovascular system in patients undergoing cardiovascular MRI COMIRB Protocol 19-1492 \| MRI-compatible exercise testing in subjects with and without congenital heart disease
	Fetal MRI and Advanced Gating Strategies COMIRB Protocol 18-2154 \| Ultrasound Gating for Cardiovascular MRI of Fetal Hemodynamics and Cardiovascular Function MRI gating and motion correction techniques for fetal cardiac MRI
	MRI measurement of mechanotransduction forces in the presence of valve disease Dr. Barker’s NIH R01 (R01HL133504) is investigating whether hemodynamic forces impact aortic aneurysm formation. This multicenter effort includes collaboration with Northwestern University and University of Calgary
	Big data biomedical image analysis and machine learning Convolutional neural networks are being trained to postprocess and stratify disease based on our large pediatric database of 4D flow and CMR imaging data. Efforts include database design, image annotation, and artificial intelligence algorithm design
	MRI Pulse sequence programming of motion control algorithms to minimize artifacts We are active in the implementation radial k-space trajectories and compressed sensing to shorten exam time and reduce motion artifact for fetal and cardiac imaging