Advancing Science with Passion
The Karam Lab is focused on the tumor immune and vascular microenvironment and how it influences cancer cell growth—especially resistance to therapy. Using various preclinical animal models, such as head and neck, pancreas, and brain cancer, many of our projects aim to decipher how to harness the power of radiation therapy (RT) as a vaccine to invigorate immune response and overcome immunosuppression. Given how many immunotherapy trials are failing these days, we have been investigating cellular mechanisms that mediate resistance to radioimmunotherapy, including:
Our work has resulted in clinical translation from bench to bedside. We have four clinical trials that represent direct translation of our preclinical work to patients. Patient tissue from the trials is then brought back to the lab to further advance scientific discovery, completing the circle.