Ming-Feng Tsai, PhD
Assistant Professor
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/ming-feng-tsai----200-x-250.jpg?sfvrsn=d37463b9_4 "Ming-Feng Tsai -- 200 x 250")
Department of Physiology and Biophysics
University of Colorado School of Medicine
RC1 North Tower, P18-7105
Mail Stop 8307
Aurora, CO 80045
E-mail: ming-feng.tsai@cuanschutz.edu
External website: http://www.tsaislab.org/
Our research focuses on molecular mechanisms and physiological functions of transporters and ion-channels, particularly Ca2+ transport proteins in mitochondria. We approach questions using a wide range of tools, including membrane-biochemistry, electrophysiology, cryo-electron microscopy, and live-cell imaging.
Please visit our external website (www.tsaislab.org) for current projects and available positions.
/chen-wei-tsai----100-x-125.jpg?sfvrsn=a8756fb9_4 "Chen-Wei Tsai -- 100 x 125") | Chen-Wei Tsai, MD, PhD Postdoctoral Fellow |
/madison-rodriguez----100-x-125.jpg?sfvrsn=5c596bb9_4 "Madison Rodriguez") | Madison Rodriguez Graduate Student |
/group-photos/tsai-lab-2023.jpg?sfvrsn=2e7414bb_2 "Tsai Lab members")
Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF*, Feng L. Structure and mechanism of the mitochondrial calcium uniporter holocomplex. Nature. (2020) 582: 129-133. *Co-corresponding.
Phillips CB, Tsai CW, & Tsai MF. The Conserved Aspartate Ring of MCU Mediates MICU1 Binding and Regulation in the Mitochondrial Calcium Uniporter Complex. eLife. (2019) 8: e41112.
Tsai CW & Tsai MF. Electrical Recordings of the Mitochondrial Calcium Uniporter in Xenopus Oocytes. Journal of General Physiology. (2018) 150: 1035-1043.
Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, & Tsai MF. Proteolytic Control of the Mitochondrial Calcium Uniporter Complex. Proc Natl Acad Sci U S A. (2017) 114: 4388-4393.
Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Williams C, & Miller C. Dual Functions of a Small Regulatory Subunit in the Mitochondrial Calcium Uniporter. eLife. (2016) 5: e15545.
Tsai MF, & Miller C. Building a Temperature-Sensitive Ion Channel. Cell. (2015) 158: 977-979
Tsai MF, Jiang D, Zhao L, Clapham D, & Miller C. Functional Reconstitution of the Mitochondrial H+/Ca2+ Exchanger Letm1. Journal of General Physiology. (2014) 143: 67-73.
Tsai MF, McCarthy P, & Miller C. Substrate Selectivity in Glutamate-Dependent Acid Resistance in Enteric Bacteria. Proc Natl Acad Sci U S A. (2013) 110: 5898-5902.
Tsai MF, & Miller C. Substrate Selectivity in Arginine-Dependent Acid Resistance in Enteric Bacteria. Proc Natl Acad Sci U S A. (2013) 110: 5893-5897.