University of Colorado Denver
Department of Pharmacology
Mail Stop 8303, RC1-North
12800 East 19th Ave
Aurora CO 80045
Phone: (303) 724-3130
Fax: (303) 724-3663
E-mail: william.sather@cuanschutz.edu
Office: RC1-North,
P18-6118
In nerve, muscle and secretory cells, voltage-gated Ca2+ channels transduce membrane electrical signals into a cytosolic Ca2+ signal that initiates a variety of cellular processes, including release of neurotransmitter, contraction of muscle and alteration of gene expression. Ca2+ channels trigger these processes by opening in response to electrical stimulation and allowing Ca2+ ions to flow into cells, where these ions act as signaling molecules that can be detected by Ca2+ binding proteins.
Our research is focused upon how voltage-gated Ca2+ channels open and selectively transport Ca2+, and how these channels are modulated by neurotransmitter receptors. The emphasis is upon the structural and mechanistic bases of these processes, making use of molecular biological, electrophysiological and optical methods. Three specific areas of research are underway:
First Name | Last Name | Middle Initial | Degree | Position |
J. Taylor | Juergens | BS | Graduate Student |
First Name | Last Name | Middle Initial | Degree | Position |
Liam | Breeze | J. | BS | Graduate Student |
Susan | Cibulski | M. | PhD | Postdoctoral Fellow |
Robin | Cloues | PhD | Postdoctoral Fellow | |
Seth | Oliveria | MD/PhD | Graduate Student | |
Joyce | Rohan | PhD | Postdoctoral Fellow | |
Jungang | Wang | MD/PhD | Postdoctoral Fellow | |
Dong-ho | Youn | PhD | Postdoctoral Fellow |