Darleen Sandoval, PhD

Professor

12801 E. 17th Ave. #7103, M8106 Sandoval_Darleen_200x300
Aurora, CO, 80045

Work Phone: 303-724-1822
Email: darleen.sandoval@cuanschutz.edu

Education:

  • 08/1996-12/2000        PhD, Exercise Science, Arizona State University, Tempe, AZ
  • 09/1994-06/1996        MS, Exercise Science, Central Washington University, Ellensburg, WA
  • 08/1989-05/1993        BS, Exercise Technology, University of New Mexico, Albuquerque, NM

Post-Doctoral Training:

  • 01/2001-12/2004        Postdoctoral Research Fellow, Endocrinology and Metabolism, Vanderbilt University, Nashville, TN

Research Interests:

I am an integrated physiologist, and my research focuses on advancing our understanding of the role of the gut-brain-axis in regulation of metabolism and revolves around two general themes. One is focused on understanding the role of a gut peptide, glucagon-like peptide-1 (GLP-1), on glucose homeostasis and how dysregulation of GLP-1 is involved with the onset of type 2 diabetes mellitus. The second focuses on the adaptations of the gut-brain axis with bariatric surgery and how this contributes to the profound weight-loss and improvements in glucose and lipid homeostasis seen with these surgeries. To do this, we utilize in vivo physiology experimental tools in genetic mouse models.

SANDOVAL LAB

Current Grants:

5 R01 DK121995-04: Mechanisms of Post-Bariatric Hypoglycemia
Sandoval, Darleen Ann, PI
06/2019-05/2023. $2,797,710

1-19-IBS-252: Defective counterregulation vs. GLP-1 in mediating increased postprandial hypoglycemia after bariatric surgery American Diabetes Association
Sandoval, PI
01/2019-12/2021. $345,000 ($114,936)

5 R01 DK115583-05: The Role of Androgens in Obesity Induced Meta-Inflammation
Co-I with Effort (Principal Investigator: Kanakadurga VNL Singer)
07/2018-04/2023. $2,185,904 ($429,656)

5 R01 DK107282-04: A novel paracrine role for GLP-1 in the islet
Darleen Ann Sandoval, PI
02/2017-01/2021. $1,556,458 ($387,500)

5 P01 DK117821-05: Gut-brain axis in metabolic disease
Co-I with Effort (Principal Investigator: Seeley, Randy J)
06/2024. ($1,860,931)

Publications:

https://www.ncbi.nlm.nih.gov/myncbi/10Slc0p8Bav54/bibliography/public/