The Owens lab uses genetic and pharmacologic tools to study BMP function in models of metastasis. Our lab hopes to uncover how diverse populations of cell in distinct niche metastatic microenvironments can be treated by modulating the BMP pathway.
Bone Morphogenetic Proteins (BMP) are members of the Transforming Growth Factor b (TGFb) family of growth factors and cytokines. The actions of BMPs can elicit many cellular transformation in development and disease. BMPs are most widely known for their original discovery at the promotion of bone formation, however they are appreciated as factors that can influence almost every cell type in the body and are frequently dysregulated in diseases such as cancer. BMPs can influence how cancer cell migrate, proliferate, survive and change their fundamental identity to promote or suppress hallmarks of cancer. BMPs are secreted factors that can also exert changes in the surrounding tumor microenvironment. The cells of the tumor microenvironment can be much more than the immune system and specialized sites of metastasis will create unique signaling with BMPs such as when breast or prostate cancers colonize the bone.
Current projects in the lab include:
University of Colorado Denver | Anschutz Medical Campus
Research Center 1 North, Room 5404J
12800 East 19th Ave
Aurora, CO 80045-0611
Education and Training: