Galambos Lab

Pulmonary vascular development is poorly understood and defective angiogenesis contributes to poor outcome of many neonatal and childhood lung disorders. Our overall scientific goal is to understand the mechanisms of lung vascular development and related disorders and develop novel strategies that lead to early diagnoses, prevention and cure of infants and children with pulmonary vascular disease. To achieve this, we integrate basic and clinical sciences, utilize human banked tissues and animal models as well as we apply unique innovative laboratory approaches. 

Currently my research laboratory focuses on characterizing and understanding the role that intrapulmonary bronchopulmonary anastomotic pathways play in severe hypoxemia in neonatal lung disorders, idiopathic pulmonary hypertension and sudden unexplained infant death, as well as the contribution of chromosome 21-related potent anti-angiogenic factors to impaired lung growth and pulmonary hypertension in infants and children with Down syndrome.


Selected publications:

  • Galambos C., Ng Y., Ali A., Noguchi A., Lovejoy S., D’Amore P., deMello D.E.: Defective pulmonary development in the absence of heparin binding VEGF isoforms.  Am J Respir Cell Mol Biol. 2002; 27:194-203.
  • Galambos C, deMello DE:  Molecular Mechanisms in Pulmonary Vascular Development. Pediatr Dev Pathol, 2007; 10:1-17.
  • Galambos C, deMello DE: Regulation of alveologenesis: clinical implication of impaired growth, Pathology, 2008; 40:124-40.
  • Nikesh, NL, Galambos C, Best-Rocha A, Malek M, Gittes GK, Potoka D:  Defective Pulmonary Innervation and Autonomic Imbalance in Congenital Diaphragmatic Hernia Am J Physiol Lung Cell Mol Physiol. 2012; 302: L390-8.
  • Galambos C, Sims-Lucas S, Abman S. Histologic Evidence of Intrapulmonary Anastomoses by Three-Dimensional Reconstruction in Severe Bronchopulmonary Dysplasia. Ann Am Thorac Soc. 2013; 10:474-81.
  • Galambos C, Sims-Lucas S, Abman S.  Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia. J Pediatr. 2014; 164:192-5.
  • Castro, EC; Parks WT, Galambos, C. The Ontogeny of Angiotensin-Converting Enzyme (ACE) And Its Aberrant Expression May Contribute to The Pathology of Bronchopulmonary Dysplasia (BPD). Pediatr Pulmonol. 2014; 49:985-90.
  • Abman SH, Baker C, Gien J, Mourani P, Galambos C. Differences between the Fetal, Newborn and Adult Pulmonary Circulations: Relevance for Age-Specific Therapies “The Robyn Barst Memorial Lecture” Pulm Circ. 2014; 4:424-40.
  • Dodson RB, Morgan M, Galambos C, Hunter KS, Abman SH. Chronic Intrauterine Pulmonary Hypertension Increases Biaxial Stiffness in Main PA Due to Adventitial Remodeling in Fetal Sheep Am J Physiol Lung Cell Mol Physiol. 2014; 307: L822-8.
  • Galambos C, Ali N, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary Shunt Pathways in Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins. Thorax. 2015; 70:84-5.
  • Acker SN, Mandell EW, Sims-Lucas S, Abman SH, Galambos C. Histologic Identification of Intrapulmonary Shunt Vessels in Congenital Diaphragmatic Hernia. J Pediatr. 2015; 166:178-83.
  • Ali N, Sims-Lucas S, Abman SH, Galambos, C. Histologic evidence of intrapulmonary bronchopulmonary anastomotic pathways in neonates with meconium aspiration syndrome J Pediatr. 2015; 167:1445-7.
  • Galambos C, Sims-Lucas S, Abman S, Cool C.  Intrapulmonary bronchopulmonary anastomotic pathways and plexiform lesions in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med. 2016; 193:574.
  • Galambos C, Bush D, Dodson RB, Minic A, Seedorf G, Abman S: Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension PLoS One. 2016; 11:e0159005.   
  • Bush D, Abman S, Galambos C. Prominent Intrapulmonary Bronchopulmonary Anastomoses and Abnormal Lung Development in Infants and Children with Down Syndrome J Pediatr. 2017; 180: 156-162.
  • Castro, EC; Sen, P; Parks, WT; Langston, C; Galambos, C; The role of serotonin transporter in human lung development and in neonatal lung disorders Can Respir J. 2017;2017:9064046. doi: 10.1155/2017/9064046. PMID: 28316463.
  • ​Bush D, Deterding R Wienman, Galambos C: Large Intrapulmonary Bronchopulmonary Anastomoses in Lipoid Pneumonia Am J Respir Crit Care Med. 2017; 195:1531-1532.
  • Bush B, Enchautegui-Colon Y, Weisfeld-Adams J, Sremba L, Galambos C, Lummus S, Wartchow E, Sherlock L, Bagrosky B, Liptzin D, Baker P. Neonatal Onset Interstitial Lung Disease as a Primary Presenting Manifestation of Mucopolysaccharidosis Type I. JIMD Rep. 2018 Apr 14. doi: 10.1007/8904_2018_101. [Epub ahead of print] PMID:29654546 
  • Bates ML, Anagnostopoulos PV, Nygard C, Torgeson J, Reichert J, Galambos C, Eldridge MW, Lamers LJ Consequences of an early catheter-based intervention on pulmonary artery growth and right ventricular myocardial function in a pig model of pulmonary artery stenosis. Catheter Cardiovasc Interv. 2018 Mar 30. doi: 10.1002/ccd.27593. [Epub ahead of print] PMID:29602248
  • Weinman JP, White C, Liptzin DR, Deterding RR, Galambos C, Browne LP. Chest High Resolution Computed Tomography findings of pulmonary interstitial glycogenosis Pediatr Radiol. 2018 Apr 23. doi: 10.1007/s00247-018-4138-4. [Epub ahead of print] PMID: 29687227 
  • Dewberry L, Bunn J, Galambos C, HI Galan, Zaretsky M, Behrendt N, Reynolds R, Meyers M, Marwan A, Liechty KW. Concurrent Extrapulmonary Bronchopulmonary Sequestration and Bronchogenic Cyst (In press, Journal of Pediatric Surgery Case Reports)
  • Bush D, Galambos C, Ivy D, Abman HS, Wolter-Warmerdam K, Hickey F: Clinical Characteristics and Risk Factors for Developing Pulmonary Hypertension in Children with Down Syndrome J Pediatr. 2018 Jul 17. pii: S0022-3476(18)30810-2. doi: 10.1016/j.jpeds.2018.06.031. [Epub ahead of print]
  • Liptzin DR,Baker CD, Darst JR, Weinman JP, Dishop MK, Galambos C, Brinton JT, Deterding RR. Pulmonary interstitial glycogenosis: diagnostic evaluation and clinical course Pediatr Pulmonol. 2018 Jul 18. doi: 10.1002/ppul.24123. PMID: 30019520
  • Galambos C, Bates ML, Bush D, Abman SH. Prominent Bronchopulmonary Vascular Anastomoses in Childhood Asthma Death. Ann Am Thorac Soc. 2018 Aug 4. doi: 10.1513/AnnalsATS.201804-262RL.PMID:30079749.
  • Gilani A, Black, JO, Weinman J, Galambos C. Sudden Death Due to Complete Airway Obstruction by Bronchial Casts (In press Am J Respir Crit Care Med)
  • McGraw MD, Houser GH, Galambos C, Warchow E, Browne LP, Stillwell PC, Weinman JP. Marijuana Medusa: The Many Pulmonary Faces of Marijuana Inhalation Abuse in Adolescent Males (In press, Pediatric Pulmonology).​

Pathology (SOM)

CU Anschutz

Academic Office One

12631 East 17th Avenue

2nd Floor

Aurora, CO 80045


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